INT115199

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Context Info
Confidence 0.79
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 19
Disease Relevance 3.65
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
bladder 3
ureter 1
urothelial cell 1
vesicles 1
skin 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 29 99.40 Very High Very High Very High
Hyperalgesia 26 98.88 Very High Very High Very High
TRP channel 79 96.52 Very High Very High Very High
induced neuropathy 1 96.52 Very High Very High Very High
Taxol 1 95.76 Very High Very High Very High
dorsal root ganglion 46 95.40 Very High Very High Very High
Mechanosensation 3 94.24 High High
imagery 21 94.08 High High
allodynia 7 92.68 High High
qutenza 67 87.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 29 99.40 Very High Very High Very High
Hyperalgesia 40 98.88 Very High Very High Very High
Nociception 25 98.28 Very High Very High Very High
Neuropathic Pain 30 96.52 Very High Very High Very High
Targeted Disruption 108 96.28 Very High Very High Very High
Ganglion Cysts 48 95.40 Very High Very High Very High
Benign Prostatic Hypertrophy 7 86.64 High High
Stress 42 82.40 Quite High
Helminth Infection 1 81.00 Quite High
Pain 106 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with its expression pattern in C. elegans and these mammalian tissues, TRPV4 localized to the cilia of polarized MDCK cells, where it colocalized with TRPP2 (Fig. 1, A–D; and Fig.
Localization (localized) of TRPV4 in MDCK
1) Confidence 0.79 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.16 Pain Relevance 0.13
Since TRPV4 channels are activated by mechanical stretch, Janssen et al. [24] evaluated the co-localization of these channels and adherence junctions (E-cadherin) in the urothelium of the human kidney, ureter, and bladder.
Localization (localization) of TRPV4 in ureter
2) Confidence 0.75 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.21 Pain Relevance 0.12
A co-localization between TRPV4 and E-cadherin was found throughout the urogenital tract.
Localization (localization) of TRPV4
3) Confidence 0.75 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.24 Pain Relevance 0.10
The same authors [25] reported that such a co-localization between TRPV4 and E-cadherin was also seen in the urothelium of normal mouse bladder but not in the TRPV4 knockout mice.
Localization (localization) of TRPV4 in bladder associated with targeted disruption
4) Confidence 0.75 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.06
The co-localization of TRPV4 and adherence junctions in the urothelium of the bladder (as well as of the other tissues) means that TRPV4 is connected to the rigid structural network that includes the intracellular actin cytoskeleton and extracellular anchoring cell junctions and confirms that TRPV4 is involved in the sensation of stretch in the urothelium of human bladder.
Localization (localization) of TRPV4 in bladder
5) Confidence 0.75 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.29 Pain Relevance 0.08
TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.


Localization (localized) of TRPV4
6) Confidence 0.72 Published 2008 Journal Acta Otolaryngol. Section Body Doc Link 18568506 Disease Relevance 0.24 Pain Relevance 0
As shown in Fig. 2A, TRPV4 was localized at the cell surface in non-stimulated cells, and stimulation by angiotensin led to robust internalization as evident by targeting of TRPV4 to intracellular vesicles.
Localization (localized) of TRPV4 in vesicles
7) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestins regulate angiotensin-induced ubiquitination of TRPV4?
Localization (ubiquitination) of TRPV4
8) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Surprisingly, angiotensin stimulation results in ubiquitination of TRPV4, a process that requires ?
Localization (ubiquitination) of TRPV4
9) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestins in angiotensin-induced ubiquitination of TRPV4, we knocked down either ?
Localization (ubiquitination) of TRPV4
10) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1 acts as an adaptor for the E3 ubiquitin ligase, AIP4, to facilitate TRPV4 ubiquitination and thus identify ?
Localization (ubiquitination) of TRPV4
11) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1, which inhibits TRPV4 ubiquitination, also blocks angiotensin-induced TRPV4 internalization provides an indication for such a possibility.
Localization (internalization) of TRPV4
12) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
First, we immunostained AT1aR and TRPV4 and examined the localization of these two proteins by confocal microscopy.
Spec (examined) Localization (localization) of TRPV4
13) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
In an immunohistochemical study, TRPV4 was localized in basal and intermediate urothelial cell layers of mice bladders, and TRPV4 expression was also confirmed in primary cell cultures.
Localization (localized) of TRPV4 in urothelial cell
14) Confidence 0.65 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.11 Pain Relevance 0.36
Co-expression of TRPV1 and TRPV4 ion channels, their modulation of synaptic transmission and their sensitization by PKC may synergistically play a role in nociception.


Localization (sensitization) of TRPV4 associated with nociception
15) Confidence 0.64 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.58 Pain Relevance 0.24
Localization of mechanosensitive channel TRPV4 in mouse skin.
Localization (Localization) of TRPV4 in skin
16) Confidence 0.62 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 14665413 Disease Relevance 0 Pain Relevance 0.12
These studies have shown that PGE2 and PAR2 mediated sensitization of TRPV4 occurs during inflammatory hyperalgesia.
Localization (sensitization) of TRPV4 associated with hyperalgesia and inflammation
17) Confidence 0.46 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 1.15 Pain Relevance 1.07
Since TRPV4 channels are activated by mechanical stretch, Janssen et al. [24] evaluated the co-localization of these channels and adherence junctions (E-cadherin) in the urothelium of the human kidney, ureter, and bladder.
Localization (localization) of TRPV4 in bladder
18) Confidence 0.25 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.21 Pain Relevance 0.12
Since TRPV4 channels are activated by mechanical stretch, Janssen et al. [24] evaluated the co-localization of these channels and adherence junctions (E-cadherin) in the urothelium of the human kidney, ureter, and bladder.
Localization (localization) of TRPV4 in kidney
19) Confidence 0.25 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.21 Pain Relevance 0.12

General Comments

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