INT115203

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.27
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
face 6
spinal 2
posterior pituitary 2
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.08 Very High Very High Very High
qutenza 30 98.36 Very High Very High Very High
Neuropeptide 7 88.12 High High
substance P 3 86.76 High High
Calcitonin gene-related peptide 7 86.08 High High
vanilloid receptor subtype 1 6 82.28 Quite High
agonist 4 81.00 Quite High
Visceral pain 3 74.72 Quite High
narcan 1 10.00 Low Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 6 99.96 Very High Very High Very High
Hypertension 6 97.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 74.72 Quite High
Overactive Bladder 2 50.00 Quite Low
Disease 1 48.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of ET(A) receptors at the hypothalamic level inhibited, whereas ET(A) receptor activation at the posterior pituitary stimulated, neurohypophysial AVP secretion.
Negative_regulation (inhibited) of Positive_regulation (Activation) of ET in posterior pituitary
1) Confidence 0.33 Published 2004 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 14665445 Disease Relevance 0 Pain Relevance 0.14
These mechanisms are reviewed, which include insufficient suppression of plasma renin activity and plasma aldosterone levels subsequent to salt loading, enhancement of sympathoexcitatory response in the face of a salt challenge, activation of the endothelin-1 receptor, and impaired natriuretic response to salt loading in capsaicin-pretreated rats.
Negative_regulation (suppression) of Positive_regulation (activation) of endothelin-1 receptor in face associated with natriuresis and qutenza
2) Confidence 0.27 Published 2003 Journal Curr Med Chem Cardiovasc Hematol Agents Section Abstract Doc Link 15320697 Disease Relevance 0.36 Pain Relevance 1.26
These mechanisms include insufficient suppression of plasma renin activity and plasma aldosterone levels subsequent to salt loading, enhancement of sympathoexcitatory response in the face of a salt challenge, activation of the endothelin-1 receptor, and impaired natriuretic response to salt loading in capsaicin-pretreated rats.
Negative_regulation (impaired) of Positive_regulation (activation) of endothelin-1 receptor in face associated with natriuresis and qutenza
3) Confidence 0.24 Published 2005 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15715923 Disease Relevance 0.35 Pain Relevance 0.74
CONCLUSIONS: These results indicate that the activation of ETA receptors in capsaicin sensitive C-fiber afferents in the bladder can induce detrusor overactivity, while ETA receptor activation in the spinal cord can inhibit the micturition reflex via activation of a spinal opioid mechanism.
Negative_regulation (inhibit) of Positive_regulation (activation) of ETA receptor in spinal
4) Confidence 0.22 Published 2004 Journal J. Urol. Section Body Doc Link 15371886 Disease Relevance 0 Pain Relevance 0
These mechanisms are reviewed, which include insufficient suppression of plasma renin activity and plasma aldosterone levels subsequent to salt loading, enhancement of sympathoexcitatory response in the face of a salt challenge, activation of the endothelin-1 receptor, and impaired natriuretic response to salt loading in capsaicin-pretreated rats.
Negative_regulation (impaired) of Positive_regulation (activation) of endothelin-1 receptor in face associated with natriuresis and qutenza
5) Confidence 0.20 Published 2003 Journal Curr Med Chem Cardiovasc Hematol Agents Section Abstract Doc Link 15320697 Disease Relevance 0.35 Pain Relevance 1.18

General Comments

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