INT115213

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.91
Pain Relevance 7.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
eyes 1
synaptic vesicle 1
nucleus 1
teeth 1
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 151 100.00 Very High Very High Very High
rheumatoid arthritis 118 100.00 Very High Very High Very High
Arthritis 68 100.00 Very High Very High Very High
Neuropeptide 37 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
endometriosis 168 99.84 Very High Very High Very High
Infliximab 212 99.48 Very High Very High Very High
antagonist 35 99.08 Very High Very High Very High
spinal inflammation 223 98.16 Very High Very High Very High
gABA 50 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 127 100.00 Very High Very High Very High
Arthritis 42 100.00 Very High Very High Very High
Endometriosis 224 99.84 Very High Very High Very High
Uveitis 43 99.84 Very High Very High Very High
Low Back Pain 265 98.16 Very High Very High Very High
Pruritus 89 96.04 Very High Very High Very High
INFLAMMATION 117 95.56 Very High Very High Very High
Discitis 4 95.12 Very High Very High Very High
Pain 52 94.76 High High
Disease 188 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up to the present few studies have experimentally been developed concerning the role of KIR genes in spondyloarthropathies (SpA) and its clear relationship with HLA-B27.
Regulation (role) of SpA
1) Confidence 0.32 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 19731638 Disease Relevance 0.24 Pain Relevance 0.20
Enthesitis affected 26% of the uSpA and 24% of the AS patients with a lower frequency in the other SpA.
Regulation (affected) of SpA
2) Confidence 0.29 Published 2009 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2656634 Disease Relevance 0.47 Pain Relevance 0.21
Provided that the same underlying mechanism is responsible for development of infusion reactions in both RA and SpA, the use of infliximab as monotherapy in a large proportion of SpA patients might have contributed to the nonsignificant difference.
Regulation (responsible) of SpA associated with infliximab and rheumatoid arthritis
3) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779374 Disease Relevance 0.58 Pain Relevance 0.62
Our data support this conclusion, as only SP duration was affected in our patient population, presumably through GABA-b receptors, whereas short ICI was normal.
Regulation (affected) of SP associated with gaba
4) Confidence 0.20 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.13 Pain Relevance 0.46
On the whole, sulfasalazine is effective for peripheral arthritis in SpA, but there is no clear option for the axial manifestations.
Regulation (effective) of SpA associated with arthritis
5) Confidence 0.11 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 1.62 Pain Relevance 1.04
The main findings of this study are: 1) AChE staining in the Pa was heterogeneously distributed along its anteroposterior and mediolateral axes; 2) the Pa harbored numerous CB- and CR-immunoreactive (ir) cells and neuropil, but this nucleus was largely devoid of PV; 3) the Pa was highly enriched in LAMP and this protein appeared uniformly distributed through its whole extent; and, 4) the SP and ENK immunoreactivities in the Pa revealed numerous highly varicose fibers scattered throughout this nucleus, but no stained cells.
Regulation (immunoreactivities) of SP in nucleus associated with enkephalin and substance p
6) Confidence 0.09 Published 2004 Journal Synapse Section Abstract Doc Link 14666515 Disease Relevance 0 Pain Relevance 0.45
There are various targets of SpA therapy (Table 1).
Regulation (targets) of SpA
7) Confidence 0.07 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 0.94 Pain Relevance 0.63
No significant changes were observed at baseline and after CPT in SP, CGRP, NPY, and VIP tear levels between eyes challenged with allergen and eyes challenged with diluent.
Regulation (changes) of SP in eyes associated with substance p
8) Confidence 0.06 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.16 Pain Relevance 0.36
At the same time, the GCF SP and MMP-8 levels of non-stimulated control teeth were unchanged.
Neg (unchanged) Regulation (unchanged) of SP in teeth
9) Confidence 0.05 Published 2008 Journal Acta Odontol. Scand. Section Body Doc Link 18320414 Disease Relevance 0.08 Pain Relevance 0
, then co-labeled for SP and synaptic vesicle 2 (SV2) protein or synaptophysin (Syn), and studied by immunofluorescence (Fig. 1A).
Regulation (labeled) of SP in synaptic vesicle associated with substance p
10) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.09 Pain Relevance 0.51
hHK-1 and SP up to 10-5 M had no impact on TNF-?
Regulation (impact) of SP associated with substance p
11) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0 Pain Relevance 0.48
This is the first clinical case series demonstrating that targeting the neuropeptide SP via applying the NKR1-antagonist aprepitant is an effective approach for the treatment of chronic pruritus in patients who all had not responded to previous therapies with topical, intralesional or systemic corticosteroids, antihistamines, and/or UV-irradiation.
Regulation (targeting) of SP associated with corticosteroid, antihistamine, antagonist, pruritus, neuropeptide and substance p
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881044 Disease Relevance 1.33 Pain Relevance 0.65
To date, published evidence on the expression of SP in endometriosis is very limited; some authors report no changes of SP in endometriosis, which could be due to the difficulties in detecting SP because it is a rather small peptide of no more than 11 amino acids [170].
Neg (no) Regulation (changes) of SP associated with endometriosis and substance p
13) Confidence 0.01 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.28 Pain Relevance 1.47

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