INT115227

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 0.15
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
reticular formation 12
motor nerve 2
nucleus 2
cortex 2
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 8 99.80 Very High Very High Very High
isoflurane 14 99.68 Very High Very High Very High
halothane 10 99.12 Very High Very High Very High
adenocard 13 99.00 Very High Very High Very High
anesthesia 18 98.72 Very High Very High Very High
Serotonin 26 98.68 Very High Very High Very High
agonist 14 98.24 Very High Very High Very High
antagonist 18 97.72 Very High Very High Very High
Potency 3 94.88 High High
tetrodotoxin 4 94.16 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 85.76 High High
Arrhythmias 2 Under Development 1 69.04 Quite High
Sprains And Strains 4 18.32 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

61 5.00 Very Low Very Low Very Low
Constipation 27 5.00 Very Low Very Low Very Low
Diarrhoea 24 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 13 5.00 Very Low Very Low Very Low
Colitis 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data support the conclusion that ACh release in PnO of B6 mouse is modulated by non-M1 muscarinic receptors.
Regulation (modulated) of Localization (release) of ACh
1) Confidence 0.60 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207318 Disease Relevance 0 Pain Relevance 0.32
These are the first neurochemical data showing that ACh release in the pontine reticular formation of the B6 mouse is modulated by NO.
Regulation (modulated) of Localization (release) of ACh in reticular formation
2) Confidence 0.59 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.06
Drug delivery by microdialysis was used in isoflurane-anesthetized C57BL/6J (B6) mice (n=33) to test the hypothesis that muscarinic autoreceptors modulate ACh release in the pontine reticular nucleus, oral part (PnO).
Regulation (modulate) of Localization (release) of ACh in nucleus associated with isoflurane
3) Confidence 0.23 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207318 Disease Relevance 0 Pain Relevance 0.32
The mouse is recognized as a powerful model for pharmacogenomics but the synaptic mechanisms regulating ACh release in mouse pontine reticular formation have not been characterized.
Regulation (regulating) of Localization (release) of ACh in reticular formation
4) Confidence 0.23 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207318 Disease Relevance 0 Pain Relevance 0.21
Considered together, results from the mouse and cat indicate that NO modulates ACh release in arousal-promoting regions of the pontine reticular formation via an NO-sensitive sGC-cGMP pathway.
Regulation (modulates) of Neg (NO) Localization (release) of ACh in reticular formation
5) Confidence 0.23 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.44
ACh regulates arousal, and the present study was designed to provide insight into the neurochemical mechanisms modulating ACh release in the pontine reticular formation.
Regulation (modulating) of Localization (release) of ACh in reticular formation
6) Confidence 0.23 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0
The finding that ODQ did not alter ACh release during isoflurane or halothane anesthesia demonstrates that these anesthetics disrupt the NO-sensitive sGC-cGMP pathway.
Neg (not) Regulation (alter) of Localization (release) of ACh associated with anesthesia, halothane and isoflurane
7) Confidence 0.23 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.47
The signal transduction cascade through which NO modulates ACh release in the pontine reticular formation has not previously been characterized.
Regulation (modulates) of Localization (release) of ACh in reticular formation
8) Confidence 0.23 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.10
Additional dual microdialysis studies revealed that ACh release in the pontine reticular formation is significantly altered by dialysis delivery of adenosine receptor agonists and antagonists to the prefrontal cortex.
Regulation (altered) of Localization (release) of ACh in cortex associated with adenocard, antagonist and agonist
9) Confidence 0.17 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19158311 Disease Relevance 0 Pain Relevance 0.71
Together, the in vitro and in vivo data show for the first time in B6 mouse that cholinergic neurotransmission in the PRF can significantly alter ACh release in frontal association cortex, arousal from anesthesia, and respiratory rate.
Regulation (alter) of Localization (release) of ACh in PRF associated with anesthesia
10) Confidence 0.14 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667438 Disease Relevance 0 Pain Relevance 0.16
Serotonin acts on the 5HT1p receptors on the terminals of submucosal IPANs resulting in the secretion of Ach and CGRP by the IPANs. 5HT4 receptors are present pre-synaptically on the distal terminals of submucosal IPANs.
Regulation (resulting) of Localization (secretion) of Ach associated with calcitonin gene related peptide and serotonin
11) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503665 Disease Relevance 0.09 Pain Relevance 0.68
To assess the changes in quantal release of ACh from the whole motor nerve terminal we used intracellular electrodes to record EPPins and mEPPins.
Regulation (changes) of Localization (release) of ACh in motor nerve
12) Confidence 0.09 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.07 Pain Relevance 0.04

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