INT115232

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.29
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ctse) peptidase activity (Ctse)
Ctse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 192 100.00 Very High Very High Very High
Glutamate 180 100.00 Very High Very High Very High
gABA 32 99.98 Very High Very High Very High
ketamine 392 99.88 Very High Very High Very High
Neurotransmitter 52 95.44 Very High Very High Very High
amygdala 160 85.76 High High
agonist 36 54.88 Quite High
epidural 1 50.00 Quite Low
antagonist 44 48.24 Quite Low
Locus ceruleus 16 47.04 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 392 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 4 21.96 Low Low
Schizophrenia 100 5.00 Very Low Very Low Very Low
Shock 44 5.00 Very Low Very Low Very Low
Cognitive Disorder 20 5.00 Very Low Very Low Very Low
Stress 20 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Psychosis 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cause of failure of CEB may depend on anatomic basis.
Negative_regulation (failure) of CEB
1) Confidence 0.36 Published 2004 Journal Clin J Pain Section Body Doc Link 14668657 Disease Relevance 0 Pain Relevance 0
Ketamine also suppresses glutamate-related fear processing in the BLA and CEA (Fig. 6A), in addition to simultaneously decreasing dopamine turnover in the CEA.
Negative_regulation (suppresses) of CEA associated with dopamine, glutamate, ketamine and anxiety disorder
2) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.16 Pain Relevance 0.88
Lastly, we propose that decreased dopamine turnover in the CEA due to ketamine administration leads to increased GABA inhibition of the BLA's outputs in the CEA, leading to decreased freezing behavior (see Fig. 7).
Negative_regulation (inhibition) of CEA associated with gaba, dopamine and ketamine
3) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.47 Pain Relevance 0.77
Ketamine also suppresses glutamate-related fear processing in the BLA and CEA (Fig. 6A), in addition to simultaneously decreasing dopamine turnover in the CEA.
Negative_regulation (decreasing) of CEA associated with dopamine, glutamate, ketamine and anxiety disorder
4) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.21 Pain Relevance 0.90
Lastly, we propose that decreased dopamine turnover in the CEA due to ketamine administration leads to increased GABA inhibition of the BLA's outputs in the CEA, leading to decreased freezing behavior (see Fig. 7).
Negative_regulation (decreased) of CEA associated with gaba, dopamine and ketamine
5) Confidence 0.28 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.46 Pain Relevance 0.82

General Comments

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