INT115238

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.78
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
spinal cord 2
pancreas 2
ducts 2
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 4 100.00 Very High Very High Very High
Spinal cord 6 99.68 Very High Very High Very High
Chronic pancreatitis 6 98.60 Very High Very High Very High
intrathecal 3 97.92 Very High Very High Very High
withdrawal 1 77.48 Quite High
anesthesia 1 75.76 Quite High
Dorsal horn 1 72.24 Quite High
Spinal sensitization 1 24.68 Low Low
Pain 4 10.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 4 100.00 Very High Very High Very High
Adenocarcinoma 3 99.84 Very High Very High Very High
Pancreatitis 6 98.60 Very High Very High Very High
Cv Unclassified Under Development 5 96.32 Very High Very High Very High
Apoptosis 2 87.52 High High
Brain Injury 2 83.44 Quite High
Nociception 3 83.12 Quite High
Adenoma 3 81.12 Quite High
Toxicity 1 78.80 Quite High
Stroke 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic cancer tissues showed a clear cytoplasmatic overexpression of Caspase-1 in tumor cells of 71% of the tumors, whereas normal pancreatic tissues showed only occasional immunoreactivity.
Spec (clear) Positive_regulation (overexpression) of Spec (clear) Gene_expression (overexpression) of Caspase-1
1) Confidence 0.68 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669344 Disease Relevance 0.16 Pain Relevance 0
In chronic pancreatitis, overexpression of Caspase-1 was found in atrophic acinar cells (89%), hyperplastic ducts (87%), and dedifferentiating acinar cells (84%).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Caspase-1 in ducts
2) Confidence 0.68 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669344 Disease Relevance 0.15 Pain Relevance 0
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Caspase-1 in pancreas associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.68 Published 2003 Journal World J. Gastroenterol. Section Title Doc Link 14669344 Disease Relevance 0.20 Pain Relevance 0.19
In contrast, no significant difference was observed for caspase 1 expression between genders.
Positive_regulation (observed) of Gene_expression (expression) of caspase 1
4) Confidence 0.23 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17166174 Disease Relevance 0.92 Pain Relevance 0.08
Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1beta-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord.
Positive_regulation (inducible) of Gene_expression (expression) of interleukin-1beta-induced in spinal cord associated with thermal hyperalgesia and spinal cord
5) Confidence 0.10 Published 2005 Journal J. Neurochem. Section Title Doc Link 16033422 Disease Relevance 0.35 Pain Relevance 0.61
CONCLUSION: M299V is an activating mutation in NLRP3 resulting in elevated spontaneous caspase 1 activity and IL-1beta levels.
Positive_regulation (resulting) of Gene_expression (activity) of caspase 1
6) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0
CONCLUSION: M299V is an activating mutation in NLRP3 resulting in elevated spontaneous caspase 1 activity and IL-1beta levels.
Positive_regulation (elevated) of Gene_expression (activity) of caspase 1
7) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0
The samples obtained from the patients displayed increased caspase 1 activity and elevated IL-1beta levels at basal conditions as compared with healthy control subjects.
Positive_regulation (elevated) of Gene_expression (activity) of caspase 1
8) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0
The samples obtained from the patients displayed increased caspase 1 activity and elevated IL-1beta levels at basal conditions as compared with healthy control subjects.
Positive_regulation (increased) of Gene_expression (activity) of caspase 1
9) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0

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