INT11524

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 6.25
Pain Relevance 18.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrd)
Anatomy Link Frequency
neurons 7
myometrium 2
spinal 2
nerve 2
retina 1
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 147 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
Pain 16 100.00 Very High Very High Very High
excitatory amino acid 8 100.00 Very High Very High Very High
nociceptor 6 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
Dopamine 156 99.98 Very High Very High Very High
long-term potentiation 21 99.92 Very High Very High Very High
Opioid 44 99.80 Very High Very High Very High
narcan 18 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 5 99.68 Very High Very High Very High
Urological Neuroanatomy 120 99.66 Very High Very High Very High
Nervous System Injury 84 99.64 Very High Very High Very High
Neuropathic Pain 87 99.60 Very High Very High Very High
Injury 18 99.44 Very High Very High Very High
Depression 16 98.88 Very High Very High Very High
Anxiety Disorder 20 98.76 Very High Very High Very High
Convulsion 68 96.60 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 12 95.32 Very High Very High Very High
INFLAMMATION 4 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The desensitization of the GABAA receptor in the presence of high concentrations of propofol may result in a suppression of the GABAA inhibitory system.


Negative_regulation (desensitization) of GABAA receptor
1) Confidence 0.58 Published 1993 Journal Anesthesiology Section Body Doc Link 8214758 Disease Relevance 0 Pain Relevance 0
However, apamin which blocks only Ca(++)-activated K+ channels had no effect on the expression of the proenkephalin gene indicating that the effect of bicuculline methiodide was due to inhibition of GABAA receptors.
Negative_regulation (inhibition) of GABAA
2) Confidence 0.45 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12732927 Disease Relevance 0 Pain Relevance 0.32
Effects of GABAA receptor inhibition on response properties of barrel cortical neurons in C-fiber-depleted rats.
Negative_regulation (inhibition) of GABAA receptor in neurons associated with c fibre and qutenza
3) Confidence 0.43 Published 2005 Journal Brain Res. Section Title Doc Link 15975565 Disease Relevance 0 Pain Relevance 0.50
Repeated subthreshold blockade of GABAA receptors in this region appears to result in a long-term 'priming' of these anxiety-like responses.
Negative_regulation (blockade) of GABAA associated with anxiety disorder
4) Confidence 0.40 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616628 Disease Relevance 0.35 Pain Relevance 0.21
Blockade of GABAA receptor function in the area of the anterior basolateral amygdala of rats elicits physiological (increases in heart rate and blood pressure) and behavioral changes similar to symptoms of human anxiety states.
Negative_regulation (Blockade) of GABAA in anterior associated with anxiety disorder and amygdala
5) Confidence 0.40 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616628 Disease Relevance 0.30 Pain Relevance 0.12
This non-naloxone reversible excitatory action of morphine was mimicked by the GABAA receptor antagonist, bicuculline, suggesting that morphine excitation was due in part to GABAA receptor blockade.
Negative_regulation (blockade) of GABAA associated with antagonist, narcan and morphine
6) Confidence 0.39 Published 1988 Journal Behav. Brain Res. Section Abstract Doc Link 2852493 Disease Relevance 0.41 Pain Relevance 0.95
The present data suggest that this allodynia could arise due to blockade of tonic GABAA and glycine-receptor mediated inhibition in the deep dorsal horn.
Negative_regulation (blockade) of GABAA in dorsal horn associated with allodynia and dorsal horn
7) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15494196 Disease Relevance 0.20 Pain Relevance 0.68
The results show that, although exogenous GABAA receptor agonist is capable of inhibiting the activity of LHRH pulse generator, the reduction in the endogenous GABAA receptor activity does not cause a significant effect, suggesting a minor role of inhibitory GABA neurons in the control of pulsatile release of LHRH.
Negative_regulation (reduction) of GABAA receptor in neurons associated with gaba and agonist
8) Confidence 0.36 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8396216 Disease Relevance 0 Pain Relevance 0.43
3 subunit seen after antigen retrieval did not differ between the two sides suggests that there is no loss of GABAA receptor from synapses after SNI.
Neg (no) Negative_regulation (loss) of GABAA receptor in synapses associated with nervous system injury
9) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2553186 Disease Relevance 0.45 Pain Relevance 0.33
The primed animals also showed increased anxiogenic responses to GABAA blockade in the BLA.
Negative_regulation (blockade) of GABAA in BLA
10) Confidence 0.35 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616628 Disease Relevance 0.48 Pain Relevance 0.28
After blocking ionotropic excitatory amino acid, and GABAA receptors with 6-cyano-7-nitro-quinoxaline-2,3-dione,D-2-amino-5-phosphonovalerate and bicuculline, respectively, the majority of deep cerebellar neurons fired spontaneously without accommodation.
Negative_regulation (blocking) of GABAA in neurons associated with excitatory amino acid
11) Confidence 0.33 Published 1995 Journal Neuroscience Section Abstract Doc Link 7715782 Disease Relevance 0 Pain Relevance 0.12
The effect of PD134,308 persisted in the presence of tetrodotoxin, after reversal of the transmembrane gradient of chloride ions and under conditions of exaggerated GABAA receptor desensitization.
Negative_regulation (desensitization) of GABAA associated with tetrodotoxin
12) Confidence 0.30 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8752577 Disease Relevance 0.07 Pain Relevance 0.39
We have examined the role of the GABAergic system in the opioid inhibition of endogenous acetylcholine (ACh) release from rat neostriatal slices by blocking either gamma-aminobutyric acid-A (GABAA) or GABAB receptors.
Negative_regulation (blocking) of GABAA associated with gabaergic and opioid
13) Confidence 0.27 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1981386 Disease Relevance 0 Pain Relevance 0.91
GABAA and GABAB antagonists prevent the opioid inhibition of endogenous acetylcholine release evoked by glutamate from rat neostriatal slices.
Negative_regulation (prevent) of GABAA associated with glutamate, antagonist, enkephalin and opioid
14) Confidence 0.27 Published 1990 Journal Neurosci. Lett. Section Title Doc Link 1981386 Disease Relevance 0 Pain Relevance 1.03
There is anatomic evidence for changes in these transmitter systems after nerve injuries, and blocking either GABAA or glycine receptors has been shown to produce allodynia-like behavior in awake normal animals.
Negative_regulation (blocking) of GABAA in nerve associated with nervous system injury and allodynia
15) Confidence 0.26 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11176099 Disease Relevance 0.37 Pain Relevance 0.31
GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat.
Negative_regulation (blockade) of GABAA-Receptor in spinal associated with qutenza, spinal dorsal horn, nociceptor and injury
16) Confidence 0.25 Published 2006 Journal J. Neurophysiol. Section Title Doc Link 16707718 Disease Relevance 0.10 Pain Relevance 1.18
Taken together with the results of gap junction and GABAA receptor blockade, these data suggest that IML field oscillations are the emergent property of a network of neurons that is dependent on synaptic properties and patterns of connections between neurons.


Negative_regulation (blockade) of GABAA receptor in neurons associated with urological neuroanatomy
17) Confidence 0.20 Published 2010 Journal Neuroscience Section Body Doc Link PMC2989444 Disease Relevance 0.47 Pain Relevance 0.23
Blockade of GABAA receptors with bicuculline inhibited the descending relaxation mediated by VIP motor neurons and the ascending contraction mediated by cholinergic motor neurons.
Negative_regulation (Blockade) of GABAA in motor neurons
18) Confidence 0.20 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1566850 Disease Relevance 0 Pain Relevance 0.59
Bilateral picrotoxin elicited a profound reduction in HR (from 300 ± 4 bpm to 176 ± 13 bpm, P < 0.01, Figure 2D); however, in contrast to activation of GABAA receptors (Figure 1D), blockade of GABAA receptors did not alter BRS (Figure 2E).
Negative_regulation (blockade) of GABAA
19) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0 Pain Relevance 0.19
To test whether inhibitory GABAergic synaptic transmission is required for rhythm generation in the IML, bicuculline, a blocker of GABAA receptors, was applied to spontaneously oscillating slices. 10 ?
Negative_regulation (blocker) of GABAA associated with gabaergic and urological neuroanatomy
20) Confidence 0.19 Published 2010 Journal Neuroscience Section Body Doc Link PMC2989444 Disease Relevance 0.15 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox