INT115253

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2004
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.56
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
plasma 4
skeletal muscle 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 85.28 High High
Disease Link Frequency Relevance Heat
Obesity 6 88.12 High High
Hyperinsulinism 3 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Spec (analyzing) Negative_regulation (analyzing) of Phosphorylation (phosphorylation) of insulin in plasma
1) Confidence 0.27 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.15 Pain Relevance 0.09
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Spec (analyzing) Negative_regulation (analyzing) of Phosphorylation (phosphorylation) of insulin in plasma
2) Confidence 0.27 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.15 Pain Relevance 0.08
Compared with NS ats, LS ats showed reduced (P < 0.01) basal and insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle and IRS-2 in live, whereas HS ats showed enhanced basal tyrosine phosphorylation of IRS-1 in skeletal muscle (P < 0.05) and of IRS-2 in live.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of insulin in skeletal muscle
3) Confidence 0.27 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.26 Pain Relevance 0.08

General Comments

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