INT115260

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Clcf1)
Anatomy Link Frequency
dentate gyrus 1
temporal lobes 1
Clcf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 22 97.36 Very High Very High Very High
bDMF 20 94.96 High High
ischemia 2 94.48 High High
antagonist 8 85.24 High High
Glutamate receptor 4 84.76 Quite High
gABA 72 75.04 Quite High
anesthesia 1 69.92 Quite High
agonist 12 5.00 Very Low Very Low Very Low
anticonvulsant 10 5.00 Very Low Very Low Very Low
GABAergic 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 44 99.52 Very High Very High Very High
Brain Hemorrhage 2 95.68 Very High Very High Very High
Malformations Of Cortical Development 2 94.16 High High
Convulsion 60 90.44 High High
Infarction 1 89.12 High High
Thrombosis 1 74.40 Quite High
Cognitive Disorder 2 60.16 Quite High
Injury 4 58.52 Quite High
Status Epilepticus 6 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BSF468248 is a novel potent complement C1 inhibitor.
Negative_regulation (inhibitor) of BSF468248
1) Confidence 0.06 Published 2003 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 14671678 Disease Relevance 0.26 Pain Relevance 0.12
Bertelli et al. have recently reported decreased levels of a Clc2 isoform in epileptic temporal lobes [25].
Negative_regulation (decreased) of Clc2 in temporal lobes associated with epilepsy
2) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.92 Pain Relevance 0.19
Amygdalar kindling of adult rats increased NKCC1 in the piriform cortex [231] and dentate gyrus [232]; decreased KCC1 and Clc2 in the dentate gyrus and Clc2 in the CA1 pyramidal region of the hippocampus, but had no effect on KCC2 [232].
Negative_regulation (decreased) of Clc2 in dentate gyrus associated with hippocampus
3) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.66 Pain Relevance 0.27

General Comments

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