INT115261

Context Info Confidence 0.05 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.31

intracellular (Nos2, Npr1) lyase activity (Npr1) aging (Nos2) peroxisome (Nos2) cytoplasm (Nos2) cytosol (Nos2)

Anatomy Link Frequency smooth muscle 3 Nos2 (Rattus norvegicus) Npr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 96.76 Inflammatory mediators 1 94.84 cINOD 1 78.00 MU agonist 1 76.24 Neurotransmitter 1 71.64

Disease Link Frequency Relevance Heat INFLAMMATION 4 96.76 Ileus 4 79.28 Intestinal Pseudo-obstruction 4 75.00 Nociception 1 62.32 Critical Illness 1 46.40 Sepsis 1 45.56 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Next, we provide evidence that production of iNOS results in the activation of guanylyl cyclase leading to the production of cGMP and smooth muscle relaxation.

Gene_expression (production) of iNOS in smooth muscle Positive_regulation (results) of Positive_regulation (activation) of guanylyl cyclase in smooth muscle

1) Confidence 0.05 Published 2003 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 14671847 Disease Relevance 0.67 Pain Relevance 0.31

General Comments

This test has worked.