INT115264

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.93
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (FECH) mitochondrion (FECH) small molecule metabolic process (FECH)
Anatomy Link Frequency
liver 2
visceral 1
FECH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 43 97.72 Very High Very High Very High
backache 20 95.08 Very High Very High Very High
Lasting pain 2 76.40 Quite High
tolerance 15 74.88 Quite High
Bile 8 66.40 Quite High
fibrosis 8 52.72 Quite High
Antihistamine 4 52.16 Quite High
Osteoarthritis 56 50.00 Quite Low
imagery 16 45.76 Quite Low
alcohol 4 34.32 Quite Low
Disease Link Frequency Relevance Heat
Erythropoietic Protoporphyria 356 100.00 Very High Very High Very High
Emergencies 4 100.00 Very High Very High Very High
Liver Disease 104 99.92 Very High Very High Very High
Hematological Disease 1 99.46 Very High Very High Very High
Disease 104 98.52 Very High Very High Very High
Hepatitis 8 97.92 Very High Very High Very High
Anaemia 46 97.84 Very High Very High Very High
Pain 21 97.72 Very High Very High Very High
Iron Overload 32 97.48 Very High Very High Very High
Pressure And Volume Under Development 25 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of the literature review indicate that few psychosocial factors have been found to be directly associated with FCE and functional measures, although many are related to various measures of disability.
FCE Binding (associated) of
1) Confidence 0.41 Published 2003 Journal J Occup Rehabil Section Abstract Doc Link 14671990 Disease Relevance 0.41 Pain Relevance 0.33
Human ABCB7 has an additional role in heme synthesis and hematopoiesis as revealed by a putative interaction between ABCB7 and FECH which has been demonstrated in pull-down assays, and anemia caused by ABCB7 depletion (83,84).
FECH Binding (interaction) of associated with hematological disease and anaemia
2) Confidence 0.29 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.70 Pain Relevance 0
All patients underwent an FCE.
FCE Binding (underwent) of
3) Confidence 0.27 Published 2008 Journal J Occup Rehabil Section Abstract Doc Link PMC2668547 Disease Relevance 0.53 Pain Relevance 0.53
Preceding the FCE tests subjectsÂ’ age and sex were registered.
FCE Binding (Preceding) of
4) Confidence 0.25 Published 2010 Journal Int Arch Occup Environ Health Section Body Doc Link PMC2980625 Disease Relevance 0.24 Pain Relevance 0.05
FCE was not associated with future recurrence, or reported pain intensity, or disability in subjects reached for follow-up.
FCE Binding (associated) of
5) Confidence 0.16 Published 2005 Journal J Occup Rehabil Section Body Doc Link 16119221 Disease Relevance 0.15 Pain Relevance 0
Liver disease develops in association with EPP in 1-4% of cases [5,6], with usual features of visceral enlargement and portal hypertension.
EPP Binding (association) of in visceral associated with liver disease, pressure and volume under development and erythropoietic protoporphyria
6) Confidence 0.08 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 1.94 Pain Relevance 0
Regarding the reduction of excess protoporhyrn in patients with EPP, two approaches can be considered:
EPP Binding (Regarding) of associated with erythropoietic protoporphyria
7) Confidence 0.06 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.55 Pain Relevance 0.09
Liver biopsy should be indicated in patients with null mutations or recessive inherited disease, patients from families with previous cases of EPP liver disease, and in individuals with EPP plus other risk factors for liver disease (such as hepatitis, haemochromatosis, alcoholic or non-alcoholic fatty liver disease, abnormal liver function tests).
EPP Binding (individuals) of in liver associated with liver disease, erythropoietic protoporphyria, alcoholic fatty liver, iron overload, disease and hepatitis
8) Confidence 0.06 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 1.83 Pain Relevance 0.06
Progressive liver disease in EPP patients should be considered a medical emergency and, therefore, liver transplantation has ben indicated in patiens with EPP.
EPP Binding (indicated) of in liver associated with liver disease, emergencies and erythropoietic protoporphyria
9) Confidence 0.06 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 1.57 Pain Relevance 0.03

General Comments

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