INT115293

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) cell-cell signaling (TXN) cytoplasm (TXN)
Anatomy Link Frequency
macrophages 2
neurons 2
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 99.56 Very High Very High Very High
Serotonin 4 99.46 Very High Very High Very High
Migraine 3 93.44 High High
lidocaine 1 89.76 High High
Calcium channel 3 83.64 Quite High
Pain 1 69.32 Quite High
Neurotransmitter 1 60.48 Quite High
Disease Link Frequency Relevance Heat
Stress 3 99.82 Very High Very High Very High
Arteritis 1 99.56 Very High Very High Very High
Targeted Disruption 1 95.76 Very High Very High Very High
Headache 3 93.44 High High
Apoptosis 1 91.40 High High
Somatoform Disorder 1 69.68 Quite High
INFLAMMATION 1 47.00 Quite Low
Increased Venous Pressure Under Development 1 35.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these data indicate that stimulation of PPARalpha in human macrophages might reduce arterial inflammation through differential regulation of the Trx-1 and VDUP-1 gene expression.
Regulation (regulation) of Gene_expression (expression) of Trx-1 in macrophages associated with arteritis and inflammation
1) Confidence 0.19 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18848838 Disease Relevance 0.19 Pain Relevance 0.14
This same UNC-2/TGF-beta pathway is required for accumulation of normal serotonin levels and stress-induced modulation of tryptophan hydroxylase (tph) expression in the serotonergic chemosensory ADF neurons, but not the NSM neurons.
Regulation (modulation) of Gene_expression (expression) of ADF in neurons associated with stress and serotonin
2) Confidence 0.03 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675154 Disease Relevance 0.59 Pain Relevance 0.59

General Comments

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