INT115294

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) small molecule metabolic process (TPH1) cellular nitrogen compound metabolic process (TPH1)
response to stress (TPH1)
Anatomy Link Frequency
chemosensory neurons 2
TPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 5 99.92 Very High Very High Very High
Calcium channel 6 99.80 Very High Very High Very High
Pain 1 98.96 Very High Very High Very High
Serotonin 8 98.80 Very High Very High Very High
antagonist 1 56.08 Quite High
Neurotransmitter 1 44.76 Quite Low
Disease Link Frequency Relevance Heat
Stress 3 100.00 Very High Very High Very High
Headache 5 99.92 Very High Very High Very High
Somatoform Disorder 1 98.96 Very High Very High Very High
Congenital Anomalies 1 91.76 High High
Convulsion 1 90.36 High High
Frailty 1 86.60 High High
Targeted Disruption 1 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase.
Regulation (involved) of Regulation (regulation) of tryptophan hydroxylase associated with stress and calcium channel
1) Confidence 0.10 Published 2004 Journal J. Neurochem. Section Title Doc Link 14675154 Disease Relevance 0.55 Pain Relevance 0.53
Previously, we have shown that in the ADF chemosensory neurons of Caenorhabditis elegans UNC-2/Ca(2+) channel function affects TGF-beta-dependent developmental regulation of tryptophan hydroxylase, the rate-limiting enzyme in serotonin synthesis.
Regulation (affects) of Regulation (regulation) of tryptophan hydroxylase in chemosensory neurons associated with serotonin
2) Confidence 0.02 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.45 Pain Relevance 0.45

General Comments

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