INT115296

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 21
Disease Relevance 7.46
Pain Relevance 10.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH1) small molecule metabolic process (TPH1) cellular nitrogen compound metabolic process (TPH1)
response to stress (TPH1)
Anatomy Link Frequency
neurons 5
brain 3
osteoblasts 1
Enterochromaffin cells 1
osteoclasts 1
TPH1 (Homo sapiens)
TPH1 - A779C (1)
Pain Link Frequency Relevance Heat
Serotonin 221 100.00 Very High Very High Very High
5HT 9 100.00 Very High Very High Very High
sSRI 187 99.56 Very High Very High Very High
Migraine 18 97.52 Very High Very High Very High
Neurotransmitter 36 96.88 Very High Very High Very High
fluoxetine 26 96.16 Very High Very High Very High
Central nervous system 36 95.36 Very High Very High Very High
Raphe 10 94.96 High High
amygdala 36 93.64 High High
antagonist 22 93.08 High High
Disease Link Frequency Relevance Heat
Disease 39 99.68 Very High Very High Very High
Stress 38 99.54 Very High Very High Very High
Headache 22 97.52 Very High Very High Very High
Targeted Disruption 10 96.98 Very High Very High Very High
Schizophrenia 96 95.48 Very High Very High Very High
Hypercalcemia 3 91.48 High High
Suicidal Behaviour 70 90.72 High High
Depression 118 90.36 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 88.76 High High
Cancer 9 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TPH1 is mainly expressed in the pineal gland, and it is responsible for peripheral serotonin response, in contrast to TPH2, which is expressed in the raphe nucleus and directly affects the serotonergic pathways of the brain [18].
Gene_expression (expressed) of TPH1 in brain associated with raphe and serotonin
1) Confidence 0.77 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.46 Pain Relevance 0.37
However, our results raise the question whether the 20% residual activity of TPH2-R441H might simply reflect a low intrinsic 5-HT synthesis capacity of PC12 cells, either due to a low endogenous TPH expression or the known substrate promiscuity of tyrosine hydroxylase [2], which is highly expressed in these catecholaminergic cells.
Gene_expression (expression) of TPH
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.10
TPH1 A779C polymorphism
Gene_expression (polymorphism) of TPH1 (A779C)
3) Confidence 0.67 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1888684 Disease Relevance 0.61 Pain Relevance 0.09
Recently, we discovered a second TPH isoform (TPH2) in vertebrates, including man, which is predominantly expressed in brain, while the previously known TPH isoform (TPH1) is primarly a non-neuronal enzyme.
Gene_expression (expressed) of TPH isoform in brain
4) Confidence 0.63 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2813293 Disease Relevance 0.27 Pain Relevance 0.11
Enterochromaffin cells were counted, and messenger RNA expression levels of tryptophan hydroxylase (TpH)-1 and serotonin reuptake transporter were determined.
Gene_expression (expression) of TpH in Enterochromaffin cells
5) Confidence 0.58 Published 2007 Journal Clin. Gastroenterol. Hepatol. Section Body Doc Link 17481962 Disease Relevance 0.09 Pain Relevance 0
Recently, a second TPH gene (TPH2) was identified, which encodes for the main 5-HT-synthesizing enzyme in neurons, whereas the previously known TPH gene (TPH1) is predominantly expressed in peripheral tissues [1], [6].
Gene_expression (expressed) of TPH1 in neurons
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.70 Pain Relevance 0.44
Recently, a second TPH gene (TPH2) was identified, which encodes for the main 5-HT-synthesizing enzyme in neurons, whereas the previously known TPH gene (TPH1) is predominantly expressed in peripheral tissues [1], [6].
Gene_expression (expressed) of TPH in neurons
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.71 Pain Relevance 0.44
Tph1 expression was also found in murine osteoblasts and osteoclasts, indicating an ability to produce serotonin.
Gene_expression (expression) of Tph1 in osteoclasts associated with serotonin
8) Confidence 0.56 Published 2006 Journal J. Cell. Biochem. Section Abstract Doc Link 16408289 Disease Relevance 0.09 Pain Relevance 0.96
Serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found, respectively, in EC cells and neurons.
Gene_expression (synthesized) of TpH1 in neurons associated with serotonin
9) Confidence 0.34 Published 2007 Journal Gastroenterology Section Abstract Doc Link 17241888 Disease Relevance 0.18 Pain Relevance 0.64
This same UNC-2/TGF-beta pathway is required for accumulation of normal serotonin levels and stress-induced modulation of tryptophan hydroxylase (tph) expression in the serotonergic chemosensory ADF neurons, but not the NSM neurons.
Gene_expression (expression) of tryptophan hydroxylase in neurons associated with stress and serotonin
10) Confidence 0.27 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675154 Disease Relevance 0.58 Pain Relevance 0.58
The demonstration that these evolutionarily related channels share a conserved ability to modulate tph expression through their effects on TGF-beta signaling provides the first specific example of how CACNA1A function may influence levels of the critical migraine neurotransmitter serotonin.
Gene_expression (expression) of tph associated with neurotransmitter, migraine and serotonin
11) Confidence 0.27 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675154 Disease Relevance 0.63 Pain Relevance 0.58
This same UNC-2/TGF-beta pathway is required for accumulation of normal serotonin levels and stress-induced modulation of tryptophan hydroxylase (tph) expression in the serotonergic chemosensory ADF neurons, but not the NSM neurons.
Gene_expression (expression) of tph in neurons associated with stress and serotonin
12) Confidence 0.27 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675154 Disease Relevance 0.57 Pain Relevance 0.58
We also show that transgenic expression of the migraine-associated Ca2+ channel, CACNA1A, in unc-2 animals can functionally substitute for UNC-2 in stress-activated regulation of tph expression.
Gene_expression (expression) of tph associated with stress, targeted disruption and migraine
13) Confidence 0.27 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675154 Disease Relevance 0.57 Pain Relevance 0.58
RT-PCR and immunostaining revealed the expression of serotonin transporter (SERT), 5HT(1A) receptors, tryptophan hydroxylase (TPH), and serotonin (5HT).
Gene_expression (expression) of tryptophan hydroxylase associated with 5ht and serotonin
14) Confidence 0.22 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.15
Tph1 expression was also found in murine osteoblasts and osteoclasts, indicating an ability to produce serotonin.
Gene_expression (expression) of Tph1 in osteoblasts associated with serotonin
15) Confidence 0.19 Published 2006 Journal J. Cell. Biochem. Section Abstract Doc Link 16408289 Disease Relevance 0.09 Pain Relevance 0.96
Tryptophan hydroxylase (TPH) is the rate-limited enzyme in 5-HT synthesis.
Gene_expression (synthesis) of Tryptophan hydroxylase
16) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.24 Pain Relevance 0.24
Overall, these data suggest that both UNC-2 and DAF-2 function are required in the developmental regulation of DAF-16 and serotonin-dependent inhibition of tryptophan hydroxylase expression.
Gene_expression (expression) of tryptophan hydroxylase associated with serotonin
17) Confidence 0.04 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.29 Pain Relevance 0.40
Here we show that developmental expression of a tryptophan hydroxylase: :GFP reporter construct is similarly decreased by reduction-of-function mutations in the daf-2/insulin receptor.
Gene_expression (expression) of tryptophan hydroxylase
18) Confidence 0.04 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.42 Pain Relevance 0.47
This decreased expression of tryptophan hydroxylase observed in both the daf-2 and unc-2 mutant backgrounds is suppressible either genetically by reduction-of-function mutations in the daf-16/forkhead transcription factor, an effector of the DAF-2/insulin receptor, or pharmacologically by the serotonin receptor antagonist cyproheptadine.
Gene_expression (expression) of tryptophan hydroxylase associated with antagonist and serotonin
19) Confidence 0.04 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16860310 Disease Relevance 0.39 Pain Relevance 0.47
A second gene coding for tryptophan hydroxylase has been identified; however, whether it is expressed in the human brain remains controversial (Patel et al 2004).
Gene_expression (expressed) of tryptophan hydroxylase in brain
20) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.24 Pain Relevance 0.30

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