INT115299

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 0.56
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napa) vesicle-mediated transport (Napa)
Anatomy Link Frequency
vesicles 1
epithelial cells 1
synapses 1
Napa (Mus musculus)
Napa - T254I (1)
Pain Link Frequency Relevance Heat
agonist 76 99.56 Very High Very High Very High
antagonist 26 97.08 Very High Very High Very High
Neurotransmitter 138 85.60 High High
imagery 72 82.16 Quite High
Nerve growth factor 17 80.60 Quite High
Dopamine 93 76.64 Quite High
qutenza 40 74.56 Quite High
Spinal cord 40 72.00 Quite High
Glutamate receptor 3 31.12 Quite Low
Glutamate 26 30.56 Quite Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 4 98.10 Very High Very High Very High
Cancer 12 96.84 Very High Very High Very High
Paralysis 26 80.28 Quite High
Ganglion Cysts 50 60.24 Quite High
Nociception 56 50.00 Quite Low
Coma 2 49.88 Quite Low
Hypoglycemia 1 32.40 Quite Low
Pain 126 21.44 Low Low
Schizophrenia 2 21.28 Low Low
Hyperalgesia 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies of the WD-40 repeat domains of M-Lgl1, M-Lgl2, Sro7, and Sro77 will be needed to understand the conserved role of Lgl family proteins in the regulation of SNARE function.


Regulation (regulation) of SNARE
1) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.06 Pain Relevance 0
The linker region may act as an intramolecular switch for tomosyn by balancing its two inhibitory effects on SNARE function.
Regulation (effects) of SNARE
2) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.15 Pain Relevance 0.07
The WD-40 repeat domain of tomosyn shares similarity to the Drosophila tumor suppressor D-Lgl, its mammalian homologues M-Lgl1 and M-Lgl2, and the yeast proteins Sro7p and Sro77p, which play important roles in polarized exocytosis by regulating SNARE function on the plasma membrane in Drosophila neuroblasts, mammalian epithelial cells, and yeast, respectively (Wirtz-Peitz and Knoblich, 2006).
Regulation (regulating) of SNARE in epithelial cells associated with cancer
3) Confidence 0.34 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.10 Pain Relevance 0.03
Collectively, these results suggest that tomosyn achieves the oligomerization of the SNARE complex via both facilitation of the formation of the monomeric SNARE complex and enhancement of the oligomerization of the preassembled SNARE complex.


Regulation (oligomerization) of SNARE
4) Confidence 0.34 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Therefore, we examined whether the phosphorylation of tomosyn altered its activity to enhance the oligomerization of the SNARE complex.
Spec (whether) Regulation (oligomerization) of SNARE
5) Confidence 0.34 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.03
In contrast, the use of SNAP25 N-terminal-derived peptides to modulate SNAP receptors (SNARE) complex assembly and neurosecretion has not been explored.
Regulation (modulate) of SNARE
6) Confidence 0.29 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0 Pain Relevance 0
The distribution and fluorescence intensity of total actin did not change significantly after the addition of SNAP.
Neg (not) Regulation (change) of SNAP
7) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.21
Synaptic efficacy at mossy fiber synapses was enhanced in tomosyn-deficient mice, suggesting that tomosyn inhibits synaptic transmission in normal animals, most likely through regulation of the oligomerization of the SNARE complex.
Regulation (regulation) of SNARE in synapses
8) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.13
These results suggest that TRPA1 and TRPV1 mediate slow-SNAP+ and fast-SNAP+ responses, respectively, demonstrating that native TRPV1 and TRPA1 are each required for normal NO sensing.
Regulation (responses) of fast-SNAP
9) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.29
AP-18 appeared to have little if any effect on the fast-SNAP+ population, while BCTC had little effect on the slow-SNAP+ population.
Neg (little) Regulation (effect) of fast-SNAP
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.23
These results suggest that TRPA1 and TRPV1 mediate slow-SNAP+ and fast-SNAP+ responses, respectively, demonstrating that native TRPV1 and TRPA1 are each required for normal NO sensing.
Regulation (responses) of slow-SNAP
11) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.30
AP-18 appeared to have little if any effect on the fast-SNAP+ population, while BCTC had little effect on the slow-SNAP+ population.
Neg (little) Regulation (effect) of slow-SNAP
12) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.24
Thus, membrane-embedded syntaxin/SNAP-25 heterodimers are available for SNARE assembly and sphingosine appears to affect specifically synaptobrevin in lipid membranes.
Regulation (available) of SNARE
13) Confidence 0.15 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
To account for the hyperactivity observed in syx3–69 flies, we next examined whether the T254I mutation in syntaxin 1A has any effect on SNARE assembly and synaptic function at permissive temperatures.
Spec (whether) Regulation (effect) of SNARE associated with attention deficit hyperactivity disorder
14) Confidence 0.05 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0.18 Pain Relevance 0
In this study, we focused on a point mutation, T254I in syntaxin 1A, located at the +7 layer of the SNARE core complex [6], and its role in SNARE complex assembly and synaptic transmission in Drosophila.
Regulation (role) of SNARE (T254I)
15) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0.08 Pain Relevance 0
Interestingly, in addition to complexin 1, proteins for both N-ethylmaleimide-sensitive factor (NSF) and soluble NSF attachment protein- (SNAP-) 25, all of which are major players in the exocytosis of neurosecretory vesicles [57], were affected by the D2 agonist.
Regulation (affected) of NSF attachment protein in vesicles associated with agonist
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0 Pain Relevance 0.18

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