INT1153

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Context Info
Confidence 0.38
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 8.61
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT3) Golgi apparatus (FUT3)
Anatomy Link Frequency
esophagus 4
LES 2
thyroid 1
neurons 1
stomach 1
FUT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 19 99.64 Very High Very High Very High
Cholecystokinin 14 98.24 Very High Very High Very High
Neuropeptide 5 95.52 Very High Very High Very High
Migraine 12 95.00 High High
palliative 12 94.96 High High
addiction 4 93.20 High High
Central nervous system 32 91.12 High High
lidocaine 4 91.12 High High
Inflammation 64 90.24 High High
cytokine 20 86.64 High High
Disease Link Frequency Relevance Heat
Dysphagia 49 99.72 Very High Very High Very High
Dyspepsia 43 99.64 Very High Very High Very High
Stress 31 99.64 Very High Very High Very High
Achalasia 316 99.48 Very High Very High Very High
Gastroesophageal Reflux Disease 163 99.30 Very High Very High Very High
Disease 143 99.00 Very High Very High Very High
Malignant Neoplastic Disease 26 97.28 Very High Very High Very High
Aging 96 95.60 Very High Very High Very High
Headache 12 95.00 High High
Cardiovascular Disease 78 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haplotype analysis for WHR in men using the FUT3 variants rs874232, rs778986, and rs11673407 identified haplotype CAG as the only one associated with WHR, compared to base haplotype TAA (p?
Negative_regulation (using) of FUT3
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.37 Pain Relevance 0
Current medical and surgical therapeutic options proposed for this well-recognized motor disorder of esophagus are aimed at reducing the LES pressure and facilitating esophageal emptying by gravity and hydrostatic pressure of retained food and liquids [8-12].
Negative_regulation (reducing) of LES in esophagus
2) Confidence 0.33 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 1.12 Pain Relevance 0.18
In both man and the opossum LES pressure was decreased significantly by either constant intravenous infusion or bolus injection of CCK.
Negative_regulation (decreased) of LES in LES associated with cholecystokinin
3) Confidence 0.30 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 165733 Disease Relevance 0 Pain Relevance 0.68
CONCLUSION: This study demonstrated a rapid and severe decrease in LES tone during prolonged cardiac arrest.
Negative_regulation (decrease) of LES in LES
4) Confidence 0.27 Published 1995 Journal Ann Emerg Med Section Body Doc Link 7618786 Disease Relevance 0.12 Pain Relevance 0
The sham group showed a nonsignificant decrease in LES pressure (p = 0.162; Table 4).
Negative_regulation (decrease) of LES
5) Confidence 0.27 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2869435 Disease Relevance 0.30 Pain Relevance 0
In contrast, intrinsic loss of inhibitory myenteric neurons in both the esophagus and LES in patients with achalasia has been reported as the most likely contributory factor in the pathophysiology of achalasia.
Negative_regulation (loss) of LES in esophagus associated with achalasia
6) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 1.24 Pain Relevance 0.16
Sublingual isosorbide dinitrate is also effective in decreasing LES pressure in achalasia patients, resulting in symptom improvement in 53% to 87% of patients.
Negative_regulation (decreasing) of LES in Sublingual associated with achalasia
7) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.24 Pain Relevance 0.11
The rational was that the injection of BT in the LES reduces the LES pressure and improves the "passive" esophageal emptying by counterbalancing the selective loss of inhibitory neurons in the myenteric plexus [2,10].
Negative_regulation (reduces) of LES in neurons
8) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.16 Pain Relevance 0
Table 1 illustrates that pretreated Patients with GERD showed heartburn, epigastric pain, and significant decrease in LES pressure, residual pressure, relaxation percentage, pH, serum gastrin and mean melatonin level and a significant increase in relaxation duration and basal acid output (BAO) relative to control group.
Negative_regulation (decrease) of LES associated with gastroesophageal reflux disease and nud
9) Confidence 0.19 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.95 Pain Relevance 0.09
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Negative_regulation (inhibitory) of LES in esophagus
10) Confidence 0.06 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
These reports are interesting in that the authors demonstrated an important role of oxidative stress in reflux due to impaired LES function.


Negative_regulation (impaired) of LES associated with stress
11) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.90 Pain Relevance 0.26
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Negative_regulation (inhibitory) of LES in pharynx
12) Confidence 0.02 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Negative_regulation (inhibitory) of LES in stomach
13) Confidence 0.02 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
Both contractile and inhibitory LES reflexes can be induced via sensory input from the pharynx, larynx, stomach, and esophagus [137].
Negative_regulation (inhibitory) of LES in larynx
14) Confidence 0.02 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0.07 Pain Relevance 0.09
After ruling out malignancy, benign strictures are managed by either balloon or bougie dilations.9 Balloon dilators are often used to treat achalasia for forceful disruption of the LES.
Negative_regulation (disruption) of LES associated with malignant neoplastic disease and dysphagia
15) Confidence 0.02 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990396 Disease Relevance 1.50 Pain Relevance 0.03
In keeping with such a hypothesis, the age-related decrease of FT3 could also be interpreted as a demographic selection favouring the subjects with low levels of thyroid hormones.
Negative_regulation (decrease) of FT3 in thyroid
16) Confidence 0.00 Published 2010 Journal Age and Ageing Section Body Doc Link PMC2956534 Disease Relevance 0.28 Pain Relevance 0.08
Our results confirm the existence of an age-related decrease in the circulating FT3 levels [2].
Negative_regulation (decrease) of FT3
17) Confidence 0.00 Published 2010 Journal Age and Ageing Section Body Doc Link PMC2956534 Disease Relevance 0.37 Pain Relevance 0.05
On the other hand, we found that of centenarians' relatives have reduced FT3, FT4 and TSH levels when compared with age-matched subjects who are not relatives of centenarians.
Negative_regulation (reduced) of FT3
18) Confidence 0.00 Published 2010 Journal Age and Ageing Section Body Doc Link PMC2956534 Disease Relevance 0.36 Pain Relevance 0.12
This finding may indicate that the decrease in circulating FT3 might specifically occur before reaching the ninth decade of life to adapt metabolic processes and to favour longevity.
Negative_regulation (decrease) of FT3 associated with aging
19) Confidence 0.00 Published 2010 Journal Age and Ageing Section Body Doc Link PMC2956534 Disease Relevance 0.42 Pain Relevance 0.10
In both groups, TSH levels increased while FT3 levels decreased significantly relative to basal values.
Negative_regulation (decreased) of FT3
20) Confidence 0.00 Published 2010 Journal J Clin Anesth Section Body Doc Link 20522354 Disease Relevance 0 Pain Relevance 0

General Comments

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