INT115300

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.00
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napa) vesicle-mediated transport (Napa)
Anatomy Link Frequency
bars 1
motor nerve 1
Napa (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 2 100.00 Very High Very High Very High
Dopamine 94 99.84 Very High Very High Very High
antagonist 5 99.46 Very High Very High Very High
Kinase C 4 99.14 Very High Very High Very High
Morphine 7 98.68 Very High Very High Very High
Neurotransmitter 13 98.20 Very High Very High Very High
antidepressant 4 91.20 High High
Glutamate 15 88.32 High High
Hippocampus 6 85.52 High High
gABA 3 80.12 Quite High
Disease Link Frequency Relevance Heat
Neuropathy 13 99.70 Very High Very High Very High
Hypolipidemia 9 92.72 High High
Dystonia 3 84.64 Quite High
Impaired Glucose Tolerance 2 82.36 Quite High
Coronary Heart Disease 4 81.40 Quite High
Babinski Reflex 3 80.24 Quite High
Dysarthria 9 76.60 Quite High
Ataxia 92 76.12 Quite High
Friedreich Ataxia 53 74.84 Quite High
Cerebellar Ataxia 48 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis.
Negative_regulation (inhibit) of SNARE
1) Confidence 0.23 Published 2004 Journal J. Neurochem. Section Title Doc Link 14675156 Disease Relevance 0.05 Pain Relevance 0.05
No involvement of NO/cGMP/cGK signaling pathway in the inhibitory effect of SNAP on dopamine release
Negative_regulation (effect) of SNAP associated with dopamine
2) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.38
When the suppressive effect of SNAP was assessed at 5 min in the absence of imipramine, ODQ (300 nM), KT5823 (1 ?
Negative_regulation (effect) of SNAP
3) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.31
Interestingly, the slow-SNAP+ population (red bars) was specifically and dramatically reduced by the TRPA1 antagonist AP-18 (100 µM), while the fast-SNAP+ population was reduced by the TRPV1 antagonist BCTC (1 µM) (Fig. 4A and Table 1).
Negative_regulation (reduced) of fast-SNAP in bars associated with antagonist
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.22
This suggests a causal relationship between the inhibition of PKC-dependent SNAP-25 phosphorylation and the down-regulation of SNARE complex formation after chronic morphine treatment.
Negative_regulation (down-regulation) of SNARE associated with kinase c and morphine
5) Confidence 0.08 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.89
Furthermore, we found a selective reduction in the expression level of the three proteins forming the core SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex.
Negative_regulation (reduction) of SNARE
6) Confidence 0.06 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15800181 Disease Relevance 0.06 Pain Relevance 0.79
Electrophysiological studies show signs of axonal sensory neuropathy with moderate reduction of sensory nerve action potentials (SNAP) and normal motor nerve conduction velocities.
Negative_regulation (reduction) of SNAP in motor nerve associated with neuropathy and action potential
7) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.88 Pain Relevance 0.05

General Comments

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