INT115300

Context Info Confidence 0.23 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 1.00 Pain Relevance 2.68

transport (Napa) vesicle-mediated transport (Napa)

Anatomy Link Frequency bars 1 motor nerve 1 Napa (Mus musculus)

Pain Link Frequency Relevance Heat Action potential 2 100.00 Dopamine 94 99.84 antagonist 5 99.46 Kinase C 4 99.14 Morphine 7 98.68 Neurotransmitter 13 98.20 antidepressant 4 91.20 Glutamate 15 88.32 Hippocampus 6 85.52 gABA 3 80.12

Disease Link Frequency Relevance Heat Neuropathy 13 99.70 Hypolipidemia 9 92.72 Dystonia 3 84.64 Impaired Glucose Tolerance 2 82.36 Coronary Heart Disease 4 81.40 Babinski Reflex 3 80.24 Dysarthria 9 76.60 Ataxia 92 76.12 Friedreich Ataxia 53 74.84 Cerebellar Ataxia 48 69.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis.

Negative_regulation (inhibit) of SNARE

1) Confidence 0.23 Published 2004 Journal J. Neurochem. Section Title Doc Link 14675156 Disease Relevance 0.05 Pain Relevance 0.05

No involvement of NO/cGMP/cGK signaling pathway in the inhibitory effect of SNAP on dopamine release

Negative_regulation (effect) of SNAP associated with dopamine

2) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.38

When the suppressive effect of SNAP was assessed at 5 min in the absence of imipramine, ODQ (300 nM), KT5823 (1 ?

Negative_regulation (effect) of SNAP

3) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.31

Interestingly, the slow-SNAP+ population (red bars) was specifically and dramatically reduced by the TRPA1 antagonist AP-18 (100 µM), while the fast-SNAP+ population was reduced by the TRPV1 antagonist BCTC (1 µM) (Fig. 4A and Table 1).

Negative_regulation (reduced) of fast-SNAP in bars associated with antagonist

4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.22

This suggests a causal relationship between the inhibition of PKC-dependent SNAP-25 phosphorylation and the down-regulation of SNARE complex formation after chronic morphine treatment.

Negative_regulation (down-regulation) of SNARE associated with kinase c and morphine

5) Confidence 0.08 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.89

Furthermore, we found a selective reduction in the expression level of the three proteins forming the core SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex.

Negative_regulation (reduction) of SNARE

6) Confidence 0.06 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15800181 Disease Relevance 0.06 Pain Relevance 0.79

Electrophysiological studies show signs of axonal sensory neuropathy with moderate reduction of sensory nerve action potentials (SNAP) and normal motor nerve conduction velocities.

Negative_regulation (reduction) of SNAP in motor nerve associated with neuropathy and action potential

7) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.88 Pain Relevance 0.05

General Comments

This test has worked.