INT115300
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis. | |||||||||||||||
| |||||||||||||||
|
No involvement of NO/cGMP/cGK signaling pathway in the inhibitory effect of SNAP on dopamine release | |||||||||||||||
| |||||||||||||||
|
When the suppressive effect of SNAP was assessed at 5 min in the absence of imipramine, ODQ (300 nM), KT5823 (1 ? | |||||||||||||||
| |||||||||||||||
|
Interestingly, the slow-SNAP+ population (red bars) was specifically and dramatically reduced by the TRPA1 antagonist AP-18 (100 µM), while the fast-SNAP+ population was reduced by the TRPV1 antagonist BCTC (1 µM) (Fig. 4A and Table 1). | |||||||||||||||
| |||||||||||||||
|
This suggests a causal relationship between the inhibition of PKC-dependent SNAP-25 phosphorylation and the down-regulation of SNARE complex formation after chronic morphine treatment. | |||||||||||||||
| |||||||||||||||
|
Furthermore, we found a selective reduction in the expression level of the three proteins forming the core SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex. | |||||||||||||||
| |||||||||||||||
|
Electrophysiological studies show signs of axonal sensory neuropathy with moderate reduction of sensory nerve action potentials (SNAP) and normal motor nerve conduction velocities. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.