INT115301

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 0.60
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napa) vesicle-mediated transport (Napa)
Anatomy Link Frequency
synaptic vesicle 4
neuronal 2
brain 2
neural 2
Napa (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 6 99.92 Very High Very High Very High
Morphine 21 99.72 Very High Very High Very High
Neurotransmitter 149 98.56 Very High Very High Very High
Kinase C 12 98.32 Very High Very High Very High
Potency 3 94.24 High High
Glutamate 15 92.68 High High
Analgesic 3 89.12 High High
Hippocampus 11 80.48 Quite High
long-term potentiation 7 78.40 Quite High
Pyramidal cell 8 52.56 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 3 91.92 High High
Coma 2 88.36 High High
Ganglion Cysts 58 83.84 Quite High
Attention Deficit Hyperactivity Disorder 4 82.84 Quite High
Paralysis 26 65.52 Quite High
Aging 1 30.08 Quite Low
Cancer 14 14.72 Low Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with a previous study (Pabst et al., 2002), complexin did not enhance the oligomerization of the SNARE complex under reducing conditions (Fig.
Negative_regulation (reducing) of SNARE Neg (not) Binding (oligomerization) of
1) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Therefore, we concluded that tomosyn potently inhibits SNARE-dependent synaptic vesicle fusion via both N-terminal WD-40 repeat domain–catalyzed oligomerization of the SNARE complex and C-terminal VLD-based competitive inhibition of SNARE complex formation.
Negative_regulation (inhibition) of SNARE Binding (formation) of in synaptic vesicle
2) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.13
Tomosyn inhibits SNARE-dependent synaptic vesicle fusion via both N-terminal WD-40 repeat domain–mediated oligomerization of the SNARE complex and C-terminal VLD-based competitive inhibition of SNARE complex formation, resulting in potent inhibition of neurotransmitter release.


Negative_regulation (inhibition) of SNARE Binding (formation) of in synaptic vesicle associated with neurotransmitter
3) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.05
The decreased immunostaining intensity for SNAP-25 is explained by the decreased formation of the oligomerized SNARE complex and the diffuse localization of SNAP-25 on the synaptic membrane in tomosyn-deficient mice.


Negative_regulation (decreased) of SNARE Binding (formation) of
4) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.03
However, in tomosyn-deficient mice, the SNARE complex formation is unexpectedly decreased.
Negative_regulation (decreased) of SNARE Binding (formation) of
5) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.17
MBP-VLD potently inhibited the formation of the ternary SNARE complex and the oligomerization of the SNARE complex in a dose-dependent manner (Fig. 6 B).
Negative_regulation (inhibited) of SNARE Binding (oligomerization) of
6) Confidence 0.32 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Reduced formation of the oligomerized SNARE complex in the tomosyn-deficient brain
Negative_regulation (Reduced) of SNARE Binding (formation) of in brain
7) Confidence 0.32 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.12
Our findings indicate that peptides patterned after the N-terminus of SNAP25 are potent inhibitors of SNARE complex formation and neuronal exocytosis.
Negative_regulation (inhibitors) of SNARE Binding (formation) of in neuronal
8) Confidence 0.20 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0.09 Pain Relevance 0.18
Peptides patterned after this protein domain are potent inhibitors of SNARE complex formation.
Negative_regulation (inhibitors) of SNARE Binding (formation) of
9) Confidence 0.20 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0.06 Pain Relevance 0.05
These peptides abrogated SNARE complex formation only when added previous to the onset of aggregate assembly.
Negative_regulation (abrogated) of SNARE Binding (formation) of
10) Confidence 0.20 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0.07 Pain Relevance 0.07
M concentration, they could promote formation of the SNARE complexes, at the same time decreasing the amount of monomeric synaptobrevin (Figure 1A).
Negative_regulation (decreasing) of SNARE Binding (formation) of
11) Confidence 0.14 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation.
Negative_regulation (regulation) of SNARE Binding (formation) of associated with morphine
12) Confidence 0.08 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.60
Thus, these results indicate that chronic morphine treatment inhibits phosphorylation of SNAP-25 at Ser187 and leads to a down-regulation of SNARE complex formation, which presents a potential molecular mechanism for the alteration of exocytotic process and neural plasticity during opiate abuse.
Negative_regulation (regulation) of SNARE Binding (formation) of in neural associated with opiate and morphine
13) Confidence 0.08 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.83
Moreover, the level of ternary complex of SNARE proteins in either synaptosomes or PC12 cells was significantly reduced after chronic morphine treatment.
Negative_regulation (reduced) of SNARE Binding (complex) of associated with morphine
14) Confidence 0.08 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.89
Taken together, all our observations show that the T254I mutation in syntaxin 1A does not block SNARE complex formation nor does it block synaptic transmission at restrictive temperatures.
Negative_regulation (block) of SNARE Binding (formation) of
15) Confidence 0.05 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0.15 Pain Relevance 0
These results further suggest that the formation of the SNARE complex is not abolished in syx3–69 mutants at the restrictive temperature.
Neg (not) Negative_regulation (abolished) of SNARE Binding (formation) of
16) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0.23 Pain Relevance 0

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