INT115303

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.43
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
vesicle 2
nerve 1
synaptic vesicle 1
synapse 1
glands 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 9 100.00 Very High Very High Very High
Morphine 65 97.16 Very High Very High Very High
Botox 61 96.30 Very High Very High Very High
Kinase C 65 95.40 Very High Very High Very High
Dopamine 1 91.44 High High
Glutamate 4 89.60 High High
Opioid 13 83.28 Quite High
Calcium channel 11 82.88 Quite High
hyperexcitability 1 80.24 Quite High
Central nervous system 12 78.64 Quite High
Disease Link Frequency Relevance Heat
Clostridium Infection 2 91.64 High High
Spasticity 30 89.20 High High
Rod Or Cone Dystrophy 2 87.28 High High
Syndrome 6 83.44 Quite High
Targeted Disruption 5 82.32 Quite High
Sleep Disorders 2 80.72 Quite High
Cognitive Disorder 5 79.76 Quite High
Pain 12 67.60 Quite High
Virus Diseases 89 66.80 Quite High
Optic Neuritis 2 61.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the use of SNAP25 N-terminal-derived peptides to modulate SNAP receptors (SNARE) complex assembly and neurosecretion has not been explored.
Localization (neurosecretion) of SNAP
1) Confidence 0.73 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0 Pain Relevance 0
REST's target genes include many necessary for terminally differentiated neuronal function, such as synapse formation (SYN1) (28), neurotransmitter secretion (SNAP25) (26) and signalling (CHRM4) (29).
Localization (secretion) of SNAP25 in synapse associated with neurotransmitter
2) Confidence 0.54 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0 Pain Relevance 0.13
SNAP25 is a synaptic protein that plays an essential role in neurotransmitter release through regulation of synaptic vesicle exocytosis [34].
Localization (release) of SNAP25 in synaptic vesicle associated with neurotransmitter
3) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.18 Pain Relevance 0.41
Many retinal signature genes encoded proteins associated with synaptic vesicle docking and fusion (SNAP25, VAMP2, SYP, SNPH), as well as vesicle exocytosis and neurotransmitter release (SYN2, SYT4).
Localization (release) of SNAP25 in vesicle associated with neurotransmitter
4) Confidence 0.47 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.39 Pain Relevance 0.38
These results are consistent with studies showing that SNP, SNAP, and L-arginine inhibited histamine-stimulated acid secretion from gastric glands isolated from animals [13,15].
Localization (secretion) of SNAP in glands
5) Confidence 0.38 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
Also the release of NO by the NO-donor SNAP 50 ?
Localization (release) of SNAP
6) Confidence 0.25 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004619 Disease Relevance 0 Pain Relevance 0.57
The intracellular target of BTX-A is the SNAP-25 (synaptosome-associated protein of molecular eight 25 kD) which is a protein essential for the successful docking and release of acetylcholine vesicles with the presynaptic vesicle.17 In contrast, BTX-B cleaves VAMP (vesicle associated membrane protein), which is also known as synaptoabrevin.18 Like SNAP-25, VAMP is essential for the docking and fusion of the synaptic vesicles to the presynaptic membrane for the release of acetylcholine.


Localization (release) of SNAP-25 in vesicles
7) Confidence 0.07 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.11 Pain Relevance 0.10
Botulinum toxin type A binds to the receptors in the presynaptic, cholinergic motor nerve terminal and is taken up by the nerve cells where the light chain of toxin cleaves a synaptosome-associated protein (SNAP-25) to inhibit acetylcholine release from the nerve terminal.
Localization (release) of SNAP-25 in nerve associated with botox
8) Confidence 0.05 Published 2010 Journal J Neurol Section Body Doc Link PMC2910313 Disease Relevance 0.76 Pain Relevance 0.24

General Comments

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