INT115304

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.24
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neuronal 1
synaptic vesicle 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 14 100.00 Very High Very High Very High
Pain 53 99.44 Very High Very High Very High
long-term potentiation 1 99.40 Very High Very High Very High
Neuronal excitability 2 96.64 Very High Very High Very High
imagery 15 95.68 Very High Very High Very High
Kinase C 65 94.96 High High
Botox 2 87.80 High High
Quantitative sensory testing 4 75.00 Quite High
palliative 1 68.00 Quite High
analgesia 1 66.48 Quite High
Disease Link Frequency Relevance Heat
Pain 59 99.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 50 90.00 High High
Infection 35 86.32 High High
Cv Unclassified Under Development 1 82.16 Quite High
Muscle Hypertonia 2 75.28 Quite High
Dementia 2 69.92 Quite High
Respiratory Syncytial Virus 1 66.32 Quite High
Chronic Disease 3 66.20 Quite High
Injury 3 65.08 Quite High
Congenital Anomalies 10 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the use of SNAP25 N-terminal-derived peptides to modulate SNAP receptors (SNARE) complex assembly and neurosecretion has not been explored.
Regulation (modulate) of SNAP
1) Confidence 0.60 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675156 Disease Relevance 0 Pain Relevance 0
SNAP-25 is not only central for neuronal exocytosis but also for the regulation of calcium responsiveness.
Regulation (regulation) of SNAP-25 in neuronal
2) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.52 Pain Relevance 0.24
A nearly identical time course of SNAP changes in the two experiments justified the comparison of separately tested CPT and VPT as a measure of modality-specific vulnerability.
Regulation (changes) of SNAP
3) Confidence 0.26 Published 2007 Journal Muscle Nerve Section Abstract Doc Link 17195168 Disease Relevance 0.08 Pain Relevance 0.29
Data is being collected from clients in both groups at baseline, three months and six months to examine short and medium term change in SNAP risk factors.
Spec (examine) Regulation (change) of SNAP
4) Confidence 0.15 Published 2010 Journal BMC Nurs Section Body Doc Link PMC2841173 Disease Relevance 0.20 Pain Relevance 0.07
A planned interim analysis was performed to evaluate safety, futility, sample size assumptions made in design of the trial, and the effect of sural SNAP amplitude on pain changes.
Regulation (effect) of SNAP associated with pain and action potential
5) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919427 Disease Relevance 0.19 Pain Relevance 0.22
SNAP was used as a positive control for NO detection.


Regulation (control) of SNAP
6) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0 Pain Relevance 0.09
It then irreversibly stops exocytosis of Acetylcholine by targeting the SNAP-25 protein element of the synaptic vesicle release complex.
Regulation (targeting) of SNAP-25 protein element in synaptic vesicle
7) Confidence 0.01 Published 2009 Journal Ulster Med J Section Body Doc Link PMC2773587 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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