INT115307

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2005
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 1.37
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcg2) plasma membrane (Abcg2) nucleus (Abcg2)
Anatomy Link Frequency
stem cell 4
face 1
stem 1
nervous system 1
hematopoietic cells 1
Abcg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 20 98.44 Very High Very High Very High
addiction 20 92.36 High High
alcohol 60 91.92 High High
cerebral cortex 40 80.16 Quite High
agonist 2 63.12 Quite High
Nicotine 2 61.68 Quite High
tetrodotoxin 2 57.60 Quite High
sodium channel 2 54.00 Quite High
Calcium channel 2 52.40 Quite High
potassium channel 2 47.76 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 190 96.64 Very High Very High Very High
Alcohol Addiction 10 92.36 High High
Neurodegenerative Disease 60 77.84 Quite High
Chromosomal Instability 20 74.72 Quite High
Fetal Alcohol Syndrome 60 72.60 Quite High
Death 50 72.08 Quite High
Cancer 20 69.76 Quite High
Genomic Instability 40 43.76 Quite Low
Congenital Anomalies 20 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical analysis demonstrates specificity of expression of Sox1, ABCG2/Bcrp1, and shows that nucleostemin labels both progenitor and stem cell populations.
Gene_expression (expression) of ABCG2 in stem cell
1) Confidence 0.75 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675165 Disease Relevance 0 Pain Relevance 0.17
Immunocytochemical analysis demonstrates specificity of expression of Sox1, ABCG2/Bcrp1, and shows that nucleostemin labels both progenitor and stem cell populations.
Gene_expression (expression) of Bcrp1 in stem cell
2) Confidence 0.58 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675165 Disease Relevance 0 Pain Relevance 0.17
These data suggest that while ethanol may not decrease the overall size of the precursor pool (the combined stem and blast pool, indicated by constant nestin mRNA expression), it decreases the diversity of stem cells within this pool (indicated by decreased numbers of cells expressing Sca-1, c-kit, CD133 and ABCG2).


Gene_expression (expressing) of ABCG2 in stem
3) Confidence 0.38 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Therefore, in our next experiment we examined the expression of the ATP-binding multidrug transporter ABCG2, an integral membrane protein that identifies stem cells in many tissues including the nervous system [48], and is considered a reliable marker for stem cells [49-52].
Spec (examined) Gene_expression (expression) of ABCG2 in nervous system
4) Confidence 0.38 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Ethanol exposure, by suppressing ABCG2 expression, may decrease the survivability of neural stem cells in the face of subsequent toxic insults, including perhaps, subsequent episodes of ethanol exposure.


Gene_expression (expression) of ABCG2 in face
5) Confidence 0.38 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.29 Pain Relevance 0.12
Figure 7A shows that ethanol significantly reduced the number of live cells that expressed ABCG2 immunofluorescence after 4 days (p < 0.05).
Gene_expression (expressed) of ABCG2
6) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
We examined the cellular expression of ABCG2 by flow cytometry in neurosphere cultures exposed to ethanol at the same dosages and time period.
Spec (examined) Gene_expression (expression) of ABCG2
7) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Ethanol significantly reduced the numbers of cells expressing the stem cell markers CD117, CD133, Sca-1 and ABCG2, without decreasing nestin expression.
Gene_expression (expressing) of ABCG2 in stem cell
8) Confidence 0.30 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1249578 Disease Relevance 0.16 Pain Relevance 0.04
On the other hand, ethanol induced asymmetric division in progenitor cells and decreased the cell surface expression of a number of stem cell markers, i.e., c-kit/CD117, Sca-1 (Ly6A/E), CD133/prominin-1 and the ABCG2 transporter.
Gene_expression (expression) of ABCG2 in stem cell
9) Confidence 0.30 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.48 Pain Relevance 0.08
Finally, ethanol suppression of the expression of multi-drug resistance transporters like ABCG2 is also likely to be clinically significant.
Gene_expression (expression) of ABCG2
10) Confidence 0.30 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.20 Pain Relevance 0.14
In contrast, ethanol significantly decreased the numbers of cells that expressed cell-surface Sca-1, c-kit, CD133 and ABCG2.
Gene_expression (expressed) of ABCG2
11) Confidence 0.30 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.10 Pain Relevance 0.07
Sca-1 (Ly6A/E) identifies hematopoietic cells with the potential to form neurons, while CD117/C-kit [67-69] and the ABCG2 multi drug-resistance transporter [48] are expressed in stem cell precursors of the rodent central nervous system.
Gene_expression (expressed) of ABCG2 in hematopoietic cells associated with central nervous system
12) Confidence 0.26 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.14 Pain Relevance 0.10

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