INT115317

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 12.79
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
monocytes 2
joints 1
striatum 1
hippocampus 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 46 98.96 Very High Very High Very High
Angina 279 98.32 Very High Very High Very High
Hippocampus 6 98.32 Very High Very High Very High
fluoxetine 4 96.14 Very High Very High Very High
antidepressant 8 95.92 Very High Very High Very High
sSRI 6 95.62 Very High Very High Very High
Nicotine 2 83.20 Quite High
ischemia 36 57.28 Quite High
Crohn's disease 5 54.16 Quite High
Snapping jaw 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 288 99.68 Very High Very High Very High
Coronary Artery Disease 657 99.62 Very High Very High Very High
Depression 56 98.96 Very High Very High Very High
Atherosclerosis 189 98.64 Very High Very High Very High
Cv General 3 Under Development 243 98.32 Very High Very High Very High
Eosinophilic Esophagitis 106 98.12 Very High Very High Very High
Disease 55 97.76 Very High Very High Very High
Stable Angina Pectoris 27 97.24 Very High Very High Very High
Hypoxia 36 96.24 Very High Very High Very High
Hyperlipidemia 63 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study revealed a striking restriction of VEGF and bFGF mRNA expression in the diabetic sub-group of the atherosclerosis patient group with stable angina pectoris while the non diabetic sub-group displayed levels similar to the normal group.
Transcription (expression) of bFGF associated with stable angina pectoris, angina, atherosclerosis and diabetes mellitus
1) Confidence 0.62 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.65 Pain Relevance 0.37
To determine the effect of fluvastatin on the mRNA expression of bFGF and VEGF in monocytes of a healthy donor we performed kinetic analysis.
Transcription (expression) of bFGF in monocytes
2) Confidence 0.62 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.30 Pain Relevance 0
We observed no significant deviation from the untreated mRNA levels for VEGF and bFGF during a 48 hour period after treatment with glucose alone or in combination with fluvastatin.
Transcription (levels) of bFGF
3) Confidence 0.62 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.38 Pain Relevance 0.16
Quantitation of the mRNA for VEGF, bFGF and TGF-?
Transcription (Quantitation) of bFGF
4) Confidence 0.59 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.40 Pain Relevance 0.22
The intra assay variability of the mRNA measurements of our in vitro short term culture system was assessed by measuring the VEGF and bFGF mRNA in triplicate cultures each.
Transcription (measuring) of bFGF
5) Confidence 0.59 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.90 Pain Relevance 0.13
Quantitation of the mRNA for VEGF, bFGF and TGF-?
Transcription (mRNA) of bFGF
6) Confidence 0.59 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.39 Pain Relevance 0.22
Furthermore we analyzed in the above model the effect of high glucose levels found in diabetic individuals and statins found in the medication of all our patients on the mRNA levels of VEGF and bFGF during a 48 hour period.
Transcription (levels) of bFGF associated with diabetes mellitus
7) Confidence 0.59 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.60 Pain Relevance 0.05
The chondrogenic cultures showed that the cell aggregates from the FGF-2-expanded cells were heavier (Figure 6a) and the GAG content (13.9 ± 1.2 ?
Transcription (aggregates) of FGF-2
8) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0 Pain Relevance 0
In the control group, FGF-2 levels were detectable in only 1 of 8 joints (13%), for a concentration of 3 pg/mL.
Transcription (levels) of FGF-2 in joints
9) Confidence 0.53 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 14676757 Disease Relevance 0 Pain Relevance 0
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Transcription (levels) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
10) Confidence 0.50 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.87 Pain Relevance 0.59
In order to investigate further the relation of the mRNA expression of VEGF, bFGF and TGF-?
Transcription (expression) of bFGF
11) Confidence 0.46 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 2.33 Pain Relevance 0.51
Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression

Background

Transcription (expression) of bFGF in monocytes associated with coronary artery disease and diabetes mellitus
12) Confidence 0.46 Published 2003 Journal J Transl Med Section Title Doc Link PMC239962 Disease Relevance 1.02 Pain Relevance 0.12
Transcripts for bFGF were found to be increased in newly diagnosed EoE subjects and expression was decreased after treatment.
Transcription (Transcripts) of bFGF associated with eosinophilic esophagitis
13) Confidence 0.38 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.08 Pain Relevance 0.03
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Transcription (levels) of FGF2 in striatum associated with antidepressant, depression, hippocampus, ssri and fluoxetine
14) Confidence 0.17 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.87 Pain Relevance 0.59

General Comments

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