INT115328

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.10
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (HM13) endoplasmic reticulum (HM13) plasma membrane (HM13)
HM13 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
cINOD 2 94.92 High High
corticosteroid 1 92.12 High High
imagery 2 78.48 Quite High
Crohn's disease 14 50.00 Quite Low
cva 3 50.00 Quite Low
headache 1 36.64 Quite Low
abdominal pain 4 33.32 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Abscess 5 99.08 Very High Very High Very High
INFLAMMATION 5 94.68 High High
Alzheimer's Dementia 8 88.00 High High
Fever 5 83.12 Quite High
Thrombosis 6 74.00 Quite High
Liver Abscess 20 72.64 Quite High
Systemic Lupus Erythematosus 1 56.12 Quite High
Disease 24 55.36 Quite High
Thrombophilia 1 51.92 Quite High
Campylobacter Infection 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SPP301 is a competitive antagonist of ET-1 with a high selectivity for the ETA receptor.
Negative_regulation (antagonist) of SPP301 associated with antagonist
1) Confidence 0.28 Published 2004 Journal J Clin Pharmacol Section Abstract Doc Link 14681342 Disease Relevance 0 Pain Relevance 0.09
Culture of the fluid revealed Peptostreptococcus spp and Propinibacterium acnes, which were both sensitive to the antibiotics administered.
Negative_regulation (revealed) of Peptostreptococcus spp
2) Confidence 0.04 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1904453 Disease Relevance 0.81 Pain Relevance 0.09
Finally, an established presenilin and SPP transition-state analog inhibitor could inhibit MCMJR1.


Negative_regulation (inhibitor) of SPP
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947513 Disease Relevance 0.20 Pain Relevance 0
Here we asked the question of whether established inhibitors of presenilin and SPP could also have an effect on MCMJR1.
Negative_regulation (inhibitors) of SPP
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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