INT115328

Context Info Confidence 0.28 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.10 Pain Relevance 0.27

peptidase activity (HM13) endoplasmic reticulum (HM13) plasma membrane (HM13)

HM13 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 100.00 cINOD 2 94.92 corticosteroid 1 92.12 imagery 2 78.48 Crohn's disease 14 50.00 cva 3 50.00 headache 1 36.64 abdominal pain 4 33.32 Inflammation 4 5.00 addiction 2 5.00

Disease Link Frequency Relevance Heat Abscess 5 99.08 INFLAMMATION 5 94.68 Alzheimer's Dementia 8 88.00 Fever 5 83.12 Thrombosis 6 74.00 Liver Abscess 20 72.64 Systemic Lupus Erythematosus 1 56.12 Disease 24 55.36 Thrombophilia 1 51.92 Campylobacter Infection 2 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SPP301 is a competitive antagonist of ET-1 with a high selectivity for the ETA receptor.

Negative_regulation (antagonist) of SPP301 associated with antagonist

1) Confidence 0.28 Published 2004 Journal J Clin Pharmacol Section Abstract Doc Link 14681342 Disease Relevance 0 Pain Relevance 0.09

Culture of the fluid revealed Peptostreptococcus spp and Propinibacterium acnes, which were both sensitive to the antibiotics administered.

Negative_regulation (revealed) of Peptostreptococcus spp

2) Confidence 0.04 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1904453 Disease Relevance 0.81 Pain Relevance 0.09

Finally, an established presenilin and SPP transition-state analog inhibitor could inhibit MCMJR1.

Negative_regulation (inhibitor) of SPP

3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947513 Disease Relevance 0.20 Pain Relevance 0

Here we asked the question of whether established inhibitors of presenilin and SPP could also have an effect on MCMJR1.

Negative_regulation (inhibitors) of SPP

4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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