INT115354

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.15
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 94 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
Morphine 24 99.98 Very High Very High Very High
Spinal nerve ligature 57 99.84 Very High Very High Very High
Neuropathic pain 50 99.36 Very High Very High Very High
Glutamate 4 96.08 Very High Very High Very High
agonist 1 95.68 Very High Very High Very High
Nucleus accumbens 8 89.68 High High
allodynia 29 89.28 High High
addiction 4 86.88 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 80 99.36 Very High Very High Very High
Cognitive Disorder 6 91.56 High High
Morphine Dependence 1 86.88 High High
Alcohol Addiction 1 75.00 Quite High
Pain 7 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Spec (whether) Regulation (altered) of NR1 Binding (association) of associated with cognitive disorder and morphine
1) Confidence 0.43 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
To investigate whether combining NMDAR antagonist ketamine with astrocytic inhibitor LAA could exert some additive and complementary effects on SNL-induced neuropathic pain, we coadministrated ketamine (100 ?
Regulation (effects) of NMDAR Binding (combining) of associated with ketamine, spinal nerve ligature, antagonist and neuropathic pain
2) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.66 Pain Relevance 1.69
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
Spec (whether) Regulation (altered) of NMDAR Binding (association) of associated with cognitive disorder and morphine
3) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
Chronic morphine altered the NMDAR inhibition by two NMDAR antagonists, 7-Cl-kynurenate and ifenprodil, but not that by d-APV or Mg2+.
Regulation (altered) of NMDAR Neg (inhibition) Binding (inhibition) of associated with antagonist and morphine
4) Confidence 0.15 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14684447 Disease Relevance 0.16 Pain Relevance 1.36

General Comments

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