INT115355

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 99.98 Very High Very High Very High
antagonist 3 99.44 Very High Very High Very High
Glutamate 8 96.08 Very High Very High Very High
agonist 1 95.68 Very High Very High Very High
Nucleus accumbens 8 89.68 High High
long-term potentiation 44 87.12 High High
addiction 4 86.88 High High
opiate 3 81.88 Quite High
nMDA receptor 45 79.16 Quite High
alcohol 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 1 86.88 High High
Alcohol Addiction 1 75.00 Quite High
Depression 44 71.92 Quite High
Drug Induced Neurotoxicity 8 12.88 Low Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Kernicterus 7 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Jaundice 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, UCB-induced decrease in NR1 subunit was not affected by addition of either leupeptin or calpeptin (Figure 10B).
Neg (not) Regulation (affected) of Negative_regulation (decrease) of NR1
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.07 Pain Relevance 0.08
Chronic morphine altered the NMDAR inhibition by two NMDAR antagonists, 7-Cl-kynurenate and ifenprodil, but not that by d-APV or Mg2+.
Regulation (altered) of Negative_regulation (inhibition) of NMDAR associated with antagonist and morphine
2) Confidence 0.09 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14684447 Disease Relevance 0.16 Pain Relevance 1.36

General Comments

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