INT115369

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.92
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSIP1) nucleoplasm (PSIP1) nucleolus (PSIP1)
nucleus (PSIP1) DNA binding (PSIP1)
PSIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 10 100.00 Very High Very High Very High
Etanercept 4 99.88 Very High Very High Very High
Adalimumab 5 98.88 Very High Very High Very High
Infliximab 7 97.76 Very High Very High Very High
spinal inflammation 31 96.40 Very High Very High Very High
Arthritis 34 96.08 Very High Very High Very High
rheumatoid arthritis 54 95.88 Very High Very High Very High
Inflammation 19 90.88 High High
antagonist 11 80.24 Quite High
psoriasis 5 62.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 97.76 Very High Very High Very High
Recurrence 12 97.56 Very High Very High Very High
Disease 83 96.72 Very High Very High Very High
Low Back Pain 33 96.40 Very High Very High Very High
Seronegative Spondarthritis 31 96.08 Very High Very High Very High
Rheumatoid Arthritis 54 95.88 Very High Very High Very High
Malignant Neoplastic Disease 2 93.32 High High
Cancer 23 93.28 High High
Second Primary Neoplasms 1 93.00 High High
Prostate Cancer 5 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etanercept is a soluble dimeric p75 TNF-?
Positive_regulation (dimeric) of Gene_expression (soluble) of p75 associated with etanercept
1) Confidence 0.49 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 2.15 Pain Relevance 1.50
CONCLUSION: The differential expression of neurotrophic factors and their cognate soluble receptors in human vasculitic neuropathy suggests that NGF, which was effectively transferred to sensory axons with p75, may induce pain.


Positive_regulation (transferred) of Gene_expression (transferred) of p75
2) Confidence 0.37 Published 2003 Journal Intern. Med. Section Body Doc Link 14686749 Disease Relevance 0 Pain Relevance 0
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Positive_regulation (represents) of Gene_expression (co-expression) of p75 associated with malignant neoplastic disease, nerve growth factor and prostate cancer
3) Confidence 0.36 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.65 Pain Relevance 0.38
For the determination overall DFS, an event is defined as the first occurrence of one of the following: inoperable disease; residual disease following surgery; local, regional or distant recurrence of tumor; second primary cancer; or death from any cause other than cancer.
Positive_regulation (overall) of Gene_expression (overall) of DFS associated with second primary neoplasms, cancer, disease, death and recurrence
4) Confidence 0.04 Published 2004 Journal BMC Cancer Section Body Doc Link PMC476737 Disease Relevance 2.13 Pain Relevance 0

General Comments

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