INT115370

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 9.45
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSIP1) nucleoplasm (PSIP1) nucleolus (PSIP1)
nucleus (PSIP1) DNA binding (PSIP1)
Anatomy Link Frequency
stem cells 2
trigeminal ganglion 1
tendon cells 1
neurons 1
nervous system 1
PSIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 56 100.00 Very High Very High Very High
nMDA receptor 4 100.00 Very High Very High Very High
Adalimumab 28 99.88 Very High Very High Very High
Etanercept 16 99.88 Very High Very High Very High
Infliximab 25 99.58 Very High Very High Very High
Trigeminal ganglion neurons 2 98.92 Very High Very High Very High
nociceptor 23 96.64 Very High Very High Very High
Arthritis 40 96.52 Very High Very High Very High
spinal inflammation 34 96.40 Very High Very High Very High
rheumatoid arthritis 104 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.82 Very High Very High Very High
Prostate Cancer 10 99.38 Very High Very High Very High
Apoptosis 5 97.76 Very High Very High Very High
Recurrence 19 97.56 Very High Very High Very High
Disease 133 96.72 Very High Very High Very High
Seronegative Spondarthritis 34 96.52 Very High Very High Very High
Low Back Pain 37 96.40 Very High Very High Very High
Rheumatoid Arthritis 104 95.88 Very High Very High Very High
Juvenile Chronic Polyarthritis 3 94.16 High High
Cancer 61 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etanercept is a soluble dimeric p75 TNF-?
Gene_expression (soluble) of p75 associated with etanercept
1) Confidence 0.65 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 2.15 Pain Relevance 1.50
antibodies (infliximab and adalimumab) and one soluble p75 TNF-?
Gene_expression (one) of p75 associated with infliximab and adalimumab
2) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174960 Disease Relevance 1.37 Pain Relevance 0.59
Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.
Gene_expression (presence) of p75 in tendon cells
3) Confidence 0.61 Published 2009 Journal Histol. Histopathol. Section Title Doc Link 19475530 Disease Relevance 0.46 Pain Relevance 0.17
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Gene_expression (co-expression) of p75 associated with malignant neoplastic disease, nerve growth factor and prostate cancer
4) Confidence 0.55 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.63 Pain Relevance 0.37
Conclusions bring to the hypothesis that the NGF network could be a candidate for future pharmacological manipulation in the PCa therapy: in particular the re-expression of p75(NTR) and/or the negative modulation of trkA could represent a target to induce apoptosis and to reduce proliferation and invasiveness of PCa.
Gene_expression (expression) of p75 associated with nerve growth factor, prostate cancer and apoptosis
5) Confidence 0.55 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.87 Pain Relevance 0.35
As the number of stem cells in the culture may not be very high, a few cells expressing p75 were observed. p75 was also expressed in limbal and conjunctival cultures as has been reported earlier [30,33].
Gene_expression (expressed) of p75 in stem cells
6) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
However, by immunohistochemistry, few cells expressing p75 were observed.
Gene_expression (expressing) of p75
7) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.08 Pain Relevance 0
As the number of stem cells in the culture may not be very high, a few cells expressing p75 were observed. p75 was also expressed in limbal and conjunctival cultures as has been reported earlier [30,33].
Gene_expression (expressing) of p75 in stem cells
8) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
Expression of p75 was also seen by RT-PCR analysis.
Gene_expression (Expression) of p75
9) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: The differential expression of neurotrophic factors and their cognate soluble receptors in human vasculitic neuropathy suggests that NGF, which was effectively transferred to sensory axons with p75, may induce pain.


Gene_expression (transferred) of p75
10) Confidence 0.49 Published 2003 Journal Intern. Med. Section Body Doc Link 14686749 Disease Relevance 0 Pain Relevance 0
NGF mRNA expression was more closely correlated with that of p75 in painful neuropathy with relatively preserved large fiber density, compared with non-painful neuropathy, though the NGF mRNA level in painful neuropathy was lower than that in non-painful neuropathy.
Gene_expression (expression) of p75
11) Confidence 0.49 Published 2003 Journal Intern. Med. Section Body Doc Link 14686749 Disease Relevance 0 Pain Relevance 0
Only a very low expression of p75 was observed in the cultured oral cells in contrast to many of the cells from the cultured limbal and conjunctival cultures, which expressed p75.


Gene_expression (expressed) of p75
12) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Only a very low expression of p75 was observed in the cultured oral cells in contrast to many of the cells from the cultured limbal and conjunctival cultures, which expressed p75.


Gene_expression (expression) of p75
13) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Expression of p75 was also checked by immunohistochemistry (Figure 4C).
Gene_expression (Expression) of p75
14) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3B, all three cell types expressed p75 as well.
Gene_expression (expressed) of p75
15) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Co-expression of the NR2B subunit of the NMDA receptor with P75 and TrkA NGF receptors by trigeminal ganglion neurons that innervate the masseter muscle was investigated immunohistochemically.
Gene_expression (Co-expression) of P75 in trigeminal ganglion associated with ganglion cysts, nerve growth factor, nmda receptor and trigeminal ganglion neurons
16) Confidence 0.39 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.24 Pain Relevance 0.89
Approximately 85% of NR2B positive masseter ganglion neurons co-expressed P75 or TrkA receptors, suggesting the potential for interaction.
Gene_expression (co-expressed) of P75 in neurons associated with ganglion cysts
17) Confidence 0.39 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.26 Pain Relevance 1.25
NGF and its receptors tyrosine kinase A and p75 are expressed not only in the developing nervous system, but also in the mature adult nervous system – where they are particularly important because of their association of primary nociceptive neurons.
Gene_expression (expressed) of p75 in nervous system associated with nociception and nerve growth factor
18) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.48 Pain Relevance 0.50
Median DFS for R0-resected patients (n?
Gene_expression (resected) of DFS
19) Confidence 0.06 Published 2010 Journal Langenbecks Arch Surg Section Body Doc Link PMC2908753 Disease Relevance 0.55 Pain Relevance 0
For the determination overall DFS, an event is defined as the first occurrence of one of the following: inoperable disease; residual disease following surgery; local, regional or distant recurrence of tumor; second primary cancer; or death from any cause other than cancer.
Gene_expression (overall) of DFS associated with second primary neoplasms, cancer, disease, death and recurrence
20) Confidence 0.05 Published 2004 Journal BMC Cancer Section Body Doc Link PMC476737 Disease Relevance 2.13 Pain Relevance 0

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