INT115374

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.36
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 4
hepatocyte 2
kidney 2
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 99.98 Very High Very High Very High
Inflammation 31 99.88 Very High Very High Very High
alcohol 24 98.24 Very High Very High Very High
fibrosis 13 5.00 Very Low Very Low Very Low
agonist 13 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 99.88 Very High Very High Very High
Fatty Liver 93 99.18 Very High Very High Very High
Liver Disease 30 98.40 Very High Very High Very High
Obesity 25 97.24 Very High Very High Very High
Injury 28 96.48 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 95 95.68 Very High Very High Very High
Hypoxia 98 86.48 High High
Nutritional Deficiencies 2 86.48 High High
Nephrotoxicity 1 81.84 Quite High
Hepatotoxicity 8 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral treatment of mice with BA resulted in a significant decrease in AP-induced CYP2E1 activity together with its inhibition of AP-induced CYP2EI expression.
Positive_regulation (induced) of Gene_expression (expression) of CYP2EI associated with paracetamol
1) Confidence 0.67 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.22 Pain Relevance 1.01
Increases in Cyp2e1 and Cyp2b expression were also evident in male kidney.
Positive_regulation (Increases) of Gene_expression (expression) of Cyp2e1 in kidney
2) Confidence 0.49 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17610925 Disease Relevance 0.66 Pain Relevance 0.07
was activated after TRI exposure in wild-type but not CYP2E1-null mice, which they attributed to a lack of CYP2E1-mediated production of TCA.
Positive_regulation (mediated) of Gene_expression (production) of CYP2E1
3) Confidence 0.46 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.24 Pain Relevance 0.03
Rats fed on this diet for 3 weeks developed several of the key features of NAFLD, including steatosis, inflammation, and increased CYP2E1 protein levels, whereas hepatocyte ballooning and Mallory bodies were not observed.
Positive_regulation (increased) of Gene_expression (levels) of CYP2E1 protein in hepatocyte associated with fatty liver and inflammation
4) Confidence 0.45 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 1.22 Pain Relevance 0.05
Increased CYP2E1 protein levels are observed in animal models of fatty liver diseases and in morbid obese men with NAFLD and patients with NASH [101, 102].
Positive_regulation (Increased) of Gene_expression (levels) of CYP2E1 in liver associated with fatty liver, liver disease, nash(non-alcoholic steatohepatitis) and obesity
5) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.03 Pain Relevance 0.08
It is likely that feeding a HFD increases CYP2E1 levels in response to elevated liver concentrations of ketones and fatty acids that serve as inducers and substrates of P450 enzymes [33].
Positive_regulation (increases) of Gene_expression (levels) of CYP2E1 in liver
6) Confidence 0.42 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.99 Pain Relevance 0.04

General Comments

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