INT115384

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 121
Total Number 123
Disease Relevance 94.74
Pain Relevance 43.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
neutrophil 8
lung 6
macrophage 5
extracellular matrix 5
skin 5
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3280 100.00 Very High Very High Very High
Inflammation 1919 100.00 Very High Very High Very High
cytokine 921 100.00 Very High Very High Very High
withdrawal 30 99.98 Very High Very High Very High
Cannabinoid 114 99.84 Very High Very High Very High
Osteoarthritis 38 99.84 Very High Very High Very High
Morphine 50 99.76 Very High Very High Very High
cINOD 39 99.56 Very High Very High Very High
Chronic pancreatitis 18 99.48 Very High Very High Very High
fibrosis 911 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2186 100.00 Very High Very High Very High
Systemic Sclerosis 1210 100.00 Very High Very High Very High
Disease 676 99.98 Very High Very High Very High
Asthma 970 99.96 Very High Very High Very High
Metastasis 358 99.92 Very High Very High Very High
Apoptosis 347 99.92 Very High Very High Very High
Interstitial Lung Diseases 96 99.92 Very High Very High Very High
Corneal Neovascularization 40 99.92 Very High Very High Very High
Diabetes Mellitus 840 99.84 Very High Very High Very High
Pneumonia 665 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased MMP-9 activity is mainly distributed in the superficial dorsal horn and colocalized primarily with neurons and small numbers of astrocytes and microglia.
Positive_regulation (increased) of MMP-9 in microglia associated with dorsal horn
1) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.30 Pain Relevance 1.24
Rapid increase in serum levels of matrix metalloproteinase-9 (MMP-9) postoperatively is associated with a decrease in the amount of intracellular MMP-9.
Positive_regulation (increase) of MMP-9 associated with metalloproteinase
2) Confidence 0.66 Published 2005 Journal Surgical innovation Section Title Doc Link 16424954 Disease Relevance 0.17 Pain Relevance 0.20
Moreover, the overexpression of MMP-9 has been reported in various pathologic conditions characterized by excessive fibrosis, including idiopathic pulmonary fibrosis, bronchial asthma, experimental biliary cirrhosis, and chronic pancreatitis [20-23], suggesting that elevated MMP-9 is closely linked to fibrogenic remodeling in target organs.
Positive_regulation (elevated) of MMP-9 associated with asthma, fibrosis, cirrhosis, pulmonary fibrosis and chronic pancreatitis
3) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.51 Pain Relevance 0.43
Elevated matrix metalloproteinase-9 in patients with systemic sclerosis

Matrix metalloproteinase-9 (MMP-9) has been implicated in the pathogenesis of cancer, autoimmune disease, and various pathologic conditions characterized by excessive fibrosis.

Positive_regulation (Elevated) of matrix metalloproteinase-9 associated with fibrosis, autoimmune disease, cancer, metalloproteinase and systemic sclerosis
4) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1064883 Disease Relevance 0.96 Pain Relevance 0.19
The levels of mRNAs and activities of MMP-2 and MMP-9 in the liver were increased from 1 h through 6 h after APAP gavage.
Positive_regulation (increased) of MMP-9 in liver associated with paracetamol
5) Confidence 0.61 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15456921 Disease Relevance 0.40 Pain Relevance 0.89
Morphine withdrawal-induced MMP-9 activity is also reduced by an nNOS inhibitor.
Positive_regulation (induced) of MMP-9 associated with withdrawal and morphine
6) Confidence 0.60 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.44 Pain Relevance 1.59
Plasma levels of MMP-9, a known protease of IGFBP-3, are significantly elevated postoperatively.
Positive_regulation (elevated) of MMP-9 in Plasma
7) Confidence 0.58 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.11 Pain Relevance 0.17
Rapid increase in serum levels of matrix metalloproteinase-9 (MMP-9) postoperatively is associated with a decrease in the amount of intracellular MMP-9.
Positive_regulation (increase) of metalloproteinase-9 associated with metalloproteinase
8) Confidence 0.58 Published 2005 Journal Surgical innovation Section Title Doc Link 16424954 Disease Relevance 0.17 Pain Relevance 0.20
MMP-9 levels are increased in internal jugular venous blood after traumatic brain injury in patients 15.
Positive_regulation (increased) of MMP-9 in internal jugular associated with metalloproteinase and brain injury
9) Confidence 0.57 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.76 Pain Relevance 0.42
The occurrence of contralateral stenosis was associated with higher MMP-9 values, suggesting that a more severe atherosclerotic disease causes elevated MMP-9 levels.
Positive_regulation (elevated) of MMP-9 associated with pathologic constriction, atherosclerosis, metalloproteinase and disease
10) Confidence 0.57 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.16 Pain Relevance 0.56
The occurrence of contralateral stenosis was associated with higher MMP-9 values, suggesting that a more severe atherosclerotic disease causes elevated MMP-9 levels.
Positive_regulation (causes) of MMP-9 associated with pathologic constriction, atherosclerosis, metalloproteinase and disease
11) Confidence 0.57 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.16 Pain Relevance 0.56
This finding suggests that activation of calcineurin and further downstream dephosphorylation of nuclear factor of activated T cells plays a role in the induction of MMP-9 [46] and that CsA may exert its therapeutic effect against SSc [47] by modulating MMP-9 activity.
Positive_regulation (induction) of MMP-9 in T cells associated with systemic sclerosis
12) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.87 Pain Relevance 0.07
The prometastatic effect of desipramine in young animals was connected with an increase of VEGF and MMP-9 plasma levels.
Positive_regulation (increase) of MMP-9 in plasma associated with desipramine and metalloproteinase
13) Confidence 0.55 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081247 Disease Relevance 0.80 Pain Relevance 0.67
Although no ROS production was detected in KO mice, their BAL gave evidence of an acute inflammatory response, as did that from WT mice: bleomycin administration elicited acute inflammation, characterized by an influx of neutrophils and associated with increased pro-MMP-9 activity.
Positive_regulation (increased) of pro-MMP-9 in neutrophils associated with inflammatory response and inflammation
14) Confidence 0.53 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.81 Pain Relevance 0.41
and MMP-9 were significantly increased in ACS group (P < 0.05) (Table 2).
Positive_regulation (increased) of MMP-9 associated with acute coronary syndrome
15) Confidence 0.50 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.13 Pain Relevance 0.18
In asthma, MMP-9 is upregulated and involved in remodeling processes [18-20].
Positive_regulation (upregulated) of MMP-9 associated with asthma
16) Confidence 0.48 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.71 Pain Relevance 0.39
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Positive_regulation (ratio) of MMP-9 associated with metalloproteinase and systemic sclerosis
17) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.91 Pain Relevance 0.17
SSc patients with the diffuse type (n = 23) and had higher concentrations of MMP-9 than those with the limited type (n = 19) (364.6 ± 32.4 ng/ml versus 260.0 ± 34.6 ng/ml, P = 0.034) (Fig. 2).
Positive_regulation (concentrations) of MMP-9 associated with systemic sclerosis
18) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.67 Pain Relevance 0
, CSF3R) and macrophage recruitment (CCL2) and/or perhaps a tissue remodeling response through activation of MMP9.
Positive_regulation (activation) of MMP9 in macrophage
19) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.82 Pain Relevance 0.07
The increased MMP-9 activity is mainly distributed in the superficial dorsal horn and colocalized primarily with neurons and small numbers of astrocytes and microglia.
Positive_regulation (distributed) of MMP-9 in microglia associated with dorsal horn
20) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.30 Pain Relevance 1.24

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