INT115385

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 154
Total Number 159
Disease Relevance 129.05
Pain Relevance 27.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
plasma 2
brain 2
intestines 2
monocyte 2
liver 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2898 100.00 Very High Very High Very High
agonist 1695 100.00 Very High Very High Very High
COX2 219 100.00 Very High Very High Very High
antagonist 107 100.00 Very High Very High Very High
cINOD 617 99.98 Very High Very High Very High
aspirin 150 99.96 Very High Very High Very High
Paracetamol 68 99.76 Very High Very High Very High
Spinal cord 46 99.68 Very High Very High Very High
Lasting pain 2 99.36 Very High Very High Very High
Sciatic nerve 4 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3330 100.00 Very High Very High Very High
Atherosclerosis 253 100.00 Very High Very High Very High
Repression 191 100.00 Very High Very High Very High
Cancer 5841 99.98 Very High Very High Very High
Apoptosis 1163 99.98 Very High Very High Very High
Obesity 1316 99.90 Very High Very High Very High
Shock 769 99.88 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 130 99.84 Very High Very High Very High
Metastasis 302 99.80 Very High Very High Very High
Targeted Disruption 418 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
has been found effective in the induction of lipogenic genes in mice deficient in PPAR?
Negative_regulation (deficient) of PPAR
1) Confidence 0.58 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.07 Pain Relevance 0
Thus, inhibition of PPAR?
Negative_regulation (inhibition) of PPAR
2) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0 Pain Relevance 0
To investigate whether downregulation of PPARalpha in NASH is the critical mechanism of compromised liver tissue repair, PPARalpha was induced in steatohepatitic mice with clofibrate (250 mg/kg for 3 days, ip) before injecting APAP.
Spec (whether) Negative_regulation (downregulation) of PPARalpha in liver associated with nash(non-alcoholic steatohepatitis) and paracetamol
3) Confidence 0.58 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.83 Pain Relevance 0.97
The objective was to investigate if the hepatotoxic sensitivity in nonalcoholic steatohepatitic mice to acetaminophen (APAP) is due to downregulation of nuclear receptor PPARalpha via lower cell division and tissue repair.
Negative_regulation (downregulation) of PPARalpha associated with paracetamol
4) Confidence 0.58 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.36 Pain Relevance 0.56
The hypothesis that impeded liver tissue repair in steatohepatitic mice was due to downregulation of PPARalpha was tested.
Negative_regulation (downregulation) of PPARalpha in liver
5) Confidence 0.58 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.83 Pain Relevance 0.96
PPARalpha was downregulated in NASH.
Negative_regulation (downregulated) of PPARalpha associated with nash(non-alcoholic steatohepatitis)
6) Confidence 0.58 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.84 Pain Relevance 0.96
Moreover, central PEA administration significantly reduced the expression of the proinflammatory enzymes cyclooxygenase-2 and inducible nitric-oxide synthase, and it significantly restored carrageenan-induced PPAR-alpha reduction in the spinal cord.
Negative_regulation (reduction) of PPAR-alpha in spinal cord associated with spinal cord
7) Confidence 0.57 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.53 Pain Relevance 0.49
showed that loss of PPAR?
Negative_regulation (loss) of PPAR
8) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.39 Pain Relevance 0.04
In a xenograft model, blocking PPAR?
Negative_regulation (blocking) of PPAR
9) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.43 Pain Relevance 0.12
inhibition of PPAR?
Negative_regulation (inhibition) of PPAR
10) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.09 Pain Relevance 0.17
cancer cells, DLD-1 and RKO, and that the loss of PPAR?
Negative_regulation (loss) of PPAR in RKO associated with cancer
11) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.94 Pain Relevance 0.08
functions as an endogenous anti-inflammatory substance in the intestines and thus that a decrease in PPAR-?
Negative_regulation (decrease) of PPAR in intestines associated with inflammation
12) Confidence 0.51 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.58 Pain Relevance 0.50
Their study shows that radiation-induced apoptosis is inhibited in PPAR-?
Negative_regulation (inhibited) of PPAR associated with apoptosis
13) Confidence 0.51 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.09 Pain Relevance 0.13
Zhao et al. showed that the reduction of PPAR levels aggravates radiation nephropathy [42].
Negative_regulation (reduction) of PPAR associated with renal disease
14) Confidence 0.51 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.07 Pain Relevance 0.13
Furthermore, the incidence of metastasis, as measured by the number of histologically identified metastatic foci, was strongly suppressed in PPAR?
Negative_regulation (suppressed) of PPAR associated with metastasis
15) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.52 Pain Relevance 0
Preliminary studies from our own laboratory indicate that treating rat brain microvascular endothelial cells with ionizing radiation or hydrogen peroxide leads to a rapid and significant reduction in PPAR?
Negative_regulation (reduction) of PPAR in endothelial cells
16) Confidence 0.50 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.85 Pain Relevance 0.21
Analysis of gene expression in postmortem brain tissue obtained from AD patients revealed significant decreases in PPAR?
Negative_regulation (decreases) of PPAR in brain associated with disease
17) Confidence 0.50 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 1.03 Pain Relevance 0.20
NSAIDs downregulate PPAR?
Negative_regulation (downregulate) of PPAR associated with cinod
18) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 1.31 Pain Relevance 0.38
and then downregulated PPAR?
Negative_regulation (downregulated) of PPAR
19) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.94 Pain Relevance 0.07
levels increase; this compensates for the decreased PPAR?
Negative_regulation (decreased) of PPAR
20) Confidence 0.43 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.90 Pain Relevance 0.03

General Comments

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