INT115386

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2011
Negated 12
Speculated 19
Reported most in Body
Documents 779
Total Number 798
Disease Relevance 549.99
Pain Relevance 128.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 21
macrophages 10
skeletal muscle 7
monocytes 7
heart 6
Ppara (Mus musculus)
Ppara - L162V (1)
Pain Link Frequency Relevance Heat
Inflammation 15448 100.00 Very High Very High Very High
agonist 12516 100.00 Very High Very High Very High
cytokine 3850 100.00 Very High Very High Very High
Cannabinoid receptor 56 100.00 Very High Very High Very High
fluoxetine 17 100.00 Very High Very High Very High
Cannabinoid 251 99.98 Very High Very High Very High
Analgesic 67 99.98 Very High Very High Very High
chemokine 703 99.96 Very High Very High Very High
antagonist 923 99.92 Very High Very High Very High
Inflammatory response 1445 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 19142 100.00 Very High Very High Very High
INFLAMMATION 17612 100.00 Very High Very High Very High
Obesity 7137 100.00 Very High Very High Very High
Disease 5210 100.00 Very High Very High Very High
Shock 4064 100.00 Very High Very High Very High
Body Weight 2969 100.00 Very High Very High Very High
Targeted Disruption 2899 100.00 Very High Very High Very High
Stress 2680 100.00 Very High Very High Very High
Sprains And Strains 1072 100.00 Very High Very High Very High
Repression 664 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several enzymes such as the 8-, 12-, 15- and 5-lipoxygeneases, the cyclooxygenases and cytochrome P450s utilize fatty acids as substrates to produce putative PPAR?
Gene_expression (produce) of PPAR
1) Confidence 0.77 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.10 Pain Relevance 0.03
(i) PEA reduced formalin-induced pain at i.pl. doses that produced no increase in systemic PEA levels; (ii) PPAR-alpha was expressed in dorsal root ganglia neurons of wild-type but not PPAR-alpha-null mice; and (ii) GW7647 and PEA prevented formalin-induced firing of spinal cord nociceptive neurons in rats.
Gene_expression (expressed) of PPAR-alpha in spinal cord associated with nociception, pain and spinal cord
2) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16997973 Disease Relevance 0.86 Pain Relevance 0.72
In addition to modulating nociception, GW7647 and PEA reduced hyperalgesic responses in the chronic constriction injury model of neuropathic pain; these effects were also contingent on PPAR-alpha expression and were observed following either acute or subchronic PPAR-alpha agonist administration.
Gene_expression (expression) of PPAR-alpha associated with nociception, hyperalgesia, eae, injury, agonist and neuropathic pain
3) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16997973 Disease Relevance 0.65 Pain Relevance 0.66
on obesity, due in part to reductions in hepatic expression of PPAR?
Gene_expression (expression) of PPAR associated with obesity
4) Confidence 0.77 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.30 Pain Relevance 0
This result suggests that presence of the PPAR?
Gene_expression (presence) of PPAR
5) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.53 Pain Relevance 0
These findings suggest that inadequate PPARalpha expression in steatohepatitic mice sensitizes them to APAP hepatotoxicity.
Gene_expression (expression) of PPARalpha associated with paracetamol and hepatotoxicity
6) Confidence 0.77 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.77 Pain Relevance 0.76
Statistically calculated mean expression levels of PPAR?
Gene_expression (expression) of PPAR
7) Confidence 0.76 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.06 Pain Relevance 0
These findings indicate that CLOCK controls the circadian expression of PPAR?
Gene_expression (expression) of PPAR
8) Confidence 0.76 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0
showed inversed phase in response to daytime feeding corresponding to altered expression of PPAR?
Gene_expression (expression) of PPAR
9) Confidence 0.76 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.10
Furthermore, brain PPAR-alpha expression is upregulated after the highest dose of repeated morphine, but not chronic cocaine, suggesting that this receptor could play a homeostatic role.
Gene_expression (expression) of PPAR-alpha in brain associated with cocaine and morphine
10) Confidence 0.76 Published 2009 Journal Neuroscience Section Abstract Doc Link 19698765 Disease Relevance 0.14 Pain Relevance 1.07
The expression of human PPAR?
Gene_expression (expression) of PPAR
11) Confidence 0.76 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.25 Pain Relevance 0
An additional and intriguing aspect of inflammation is the putative link between inflammation and impaired PPAR expression.
Gene_expression (expression) of PPAR associated with inflammation
12) Confidence 0.75 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 1.13 Pain Relevance 0.21
isotypes, the expression of PPAR?
Gene_expression (expression) of PPAR
13) Confidence 0.75 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.33 Pain Relevance 0.08
Expression of proteins closely associated with energy metabolism and insulin signaling including PPAR?
Gene_expression (Expression) of PPAR
14) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.57 Pain Relevance 0.07
play a central role in mediating PPAR-induced effects

[7–9], and the expression of both PPARs and RXRs decreases

Gene_expression (expression) of PPAR
15) Confidence 0.75 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.52 Pain Relevance 0.46
of this review, each of the PPAR isoforms is expressed in cells of the monocyte/macrophage
Gene_expression (expressed) of PPAR in macrophage
16) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.52 Pain Relevance 0.03
The species differences may be attributable to lower PPAR mRNA expression levels in h-hepatocytes compared with rodent cells [56, 57].
Gene_expression (expression) of PPAR mRNA in hepatocytes
17) Confidence 0.73 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.19 Pain Relevance 0.04
In line with this, the expression of PPAR?
Gene_expression (expression) of PPAR
18) Confidence 0.71 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.05 Pain Relevance 0.03
Thus, the expression of PPAR?
Gene_expression (expression) of PPAR
19) Confidence 0.71 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0 Pain Relevance 0.11
MS

patients showed a decrease in the expression of PPAR?

Gene_expression (expression) of PPAR associated with multiple sclerosis
20) Confidence 0.71 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.22 Pain Relevance 0.52

General Comments

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