INT115391

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 24
Disease Relevance 9.43
Pain Relevance 6.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 11
brain 5
caudate putamen 1
arms 1
prefrontal 1
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
electroacupuncture 273 99.84 Very High Very High Very High
amygdala 308 99.74 Very High Very High Very High
Inflammation 335 99.60 Very High Very High Very High
Morphine 7 99.40 Very High Very High Very High
Inflammatory response 41 98.36 Very High Very High Very High
Glutamate 198 98.24 Very High Very High Very High
antidepressant 78 96.32 Very High Very High Very High
Somatosensory cortex 14 94.64 High High
abdominal pain 21 94.28 High High
spastic colon 119 91.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 400 99.60 Very High Very High Very High
Urological Neuroanatomy 32 98.98 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

420 98.86 Very High Very High Very High
Stress 502 98.36 Very High Very High Very High
Abdominal Pain 21 94.28 High High
Anxiety Disorder 96 93.52 High High
Congenital Anomalies 23 92.00 High High
Pressure And Volume Under Development 108 91.56 High High
Pneumonia 14 90.24 High High
Hyperalgesia 48 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HR rats withdrawn from progesterone and estradiol, spent less time on the EPM open arms and had lower CORT levels than the HR controls.
Gene_expression (levels) of CORT in arms
1) Confidence 0.59 Published 2009 Journal Physiol. Behav. Section Abstract Doc Link 18793660 Disease Relevance 0.50 Pain Relevance 0.36
CHOL and CORT were placed in the brain as micropellets of the dry powder of the chemical.
Gene_expression (placed) of CORT in brain
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.04
CHOL, CORT and choral hydrate were obtained from Sigma-Aldrich (St.
Gene_expression (CHOL) of CORT
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.04
The current study demonstrates that, not only does luminal distension activate these structures in rodents, but also that CORT administration leads to a greater increase in the activation of these structures as well as the recruitment of other brain areas that were not activated in CHOL controls.
Gene_expression (administration) of CORT in brain
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.15 Pain Relevance 0.44
In conclusion, the present study provides evidence of increased brain activation, measured as increased MRI signal, in response to CRD in rats, following exposure of the amygdala to elevated levels of CORT for 7 days.
Gene_expression (levels) of CORT in brain associated with amygdala
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.28
Additionally, brain regions that form descending efferent pathways such as the basal ganglia exhibited activation in MRI signal in CORT but not CHOL-treated rats in response to 40 mmHg.
Neg (not) Gene_expression (signal) of CORT in brain
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.09 Pain Relevance 0.25
Moreover, although there is a close relationship between the amygdala and the ventrocaudal caudate putamen, previous studies using autoradiography have shown limited binding of CORT [49], due to minimal expression of GR with no appreciable MR in the ventrocaudal caudate putamen [50].
Gene_expression (expression) of CORT in caudate putamen associated with amygdala
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.31
Here the levels of CORT were rapidly elevated in serum after FS-stress (Fig. 3A–B), whether rats were treated with antidepressants or not (F3,15?
Gene_expression (levels) of CORT associated with stress and antidepressant
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.67 Pain Relevance 0.51
Our results showed that there are significant differences in brain activation in rats in response to modulation of the amygdala via elevated levels of CORT.
Gene_expression (levels) of CORT in brain associated with amygdala
9) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.35 Pain Relevance 0.58
As shown in Fig. 1, plasma CORT levels in EA-treated inflamed rats were significantly higher at 2 and 5 h post-CFA injection than those in sham-treated inflamed rats, the plasma CORT levels of which did not significantly change compared to base levels during the same period.
Gene_expression (levels) of CORT in plasma associated with electroacupuncture
10) Confidence 0.46 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.24 Pain Relevance 0.35
We found that EA significantly increased plasma CORT levels in CFA-inflamed rats compared to sham EA.
Gene_expression (levels) of CORT in plasma associated with electroacupuncture
11) Confidence 0.45 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.77 Pain Relevance 1.04
We also found that EA increased plasma CORT levels in inflamed rats but did not affect levels in naive rats.
Gene_expression (levels) of CORT in plasma associated with electroacupuncture
12) Confidence 0.45 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.79 Pain Relevance 0.80
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Gene_expression (levels) of CORT in frontal cortex associated with stress, glutamate and urological neuroanatomy
13) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.75 Pain Relevance 0.28
At baseline, ACTH levels were similar in the two groups, while CORT levels tended higher in PCO rats.
Gene_expression (levels) of CORT
14) Confidence 0.38 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236959 Disease Relevance 0.44 Pain Relevance 0.08
At 30 and 60 minutes, CORT levels were significantly higher in the PCO group.


Gene_expression (levels) of CORT
15) Confidence 0.38 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236959 Disease Relevance 0.28 Pain Relevance 0.07
In experiment 1, plasma levels of ACTH and CORT in prenatally morphine-, saline-exposed and control male rats were determined before and at several times after restraint stress.
Gene_expression (levels) of CORT in plasma associated with stress and morphine
16) Confidence 0.37 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.64 Pain Relevance 0.34
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Gene_expression (levels) of CORT in prefrontal associated with stress, glutamate and urological neuroanatomy
17) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.75 Pain Relevance 0.28
Plasma CORT and ACTH concentrations
Gene_expression (concentrations) of Plasma CORT in Plasma
18) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 0.06 Pain Relevance 0
Plasma ACTH and CORT assay
Gene_expression (assay) of CORT in Plasma
19) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 0 Pain Relevance 0
To test the hypothesis that LTB4 exerts its inhibitory effects via the HPA axis, we measured levels of CORT and ACTH in plasma 30 min after vehicle, LTB4, or U75302 via i.c.v. administration, and 180 min after antigen challenge.
Gene_expression (levels) of CORT in plasma
20) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 0.05 Pain Relevance 0

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