INT115392

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.31
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink1)
Anatomy Link Frequency
parotid gland 2
Spink1 (Rattus norvegicus)
Spink1 - N34S (2)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 17 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 25 98.64 Very High Very High Very High
Parotitis 6 96.12 Very High Very High Very High
Adenocarcinoma 4 95.64 Very High Very High Very High
Pancreatic Cancer 6 93.32 High High
Cholecystitis 1 90.88 High High
Colon Cancer 1 64.72 Quite High
Alcoholic Pancreatitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The SPINK1 gene is transcribed in the parotid gland.
Transcription (transcribed) of SPINK1 gene in parotid gland
1) Confidence 0.69 Published 2004 Journal Dig Dis Section Body Doc Link 15753612 Disease Relevance 0.09 Pain Relevance 0
METHODS: Reverse-transcriptase polymerase chain reaction was used to investigate SPINK1 transcription in the parotid gland.
Spec (investigate) Transcription (transcription) of SPINK1 in parotid gland
2) Confidence 0.69 Published 2004 Journal Dig Dis Section Body Doc Link 15753612 Disease Relevance 0.10 Pain Relevance 0
Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene.
Transcription (Detection) of SPINK1
3) Confidence 0.57 Published 2006 Journal Eur. J. Hum. Genet. Section Title Doc Link 16823394 Disease Relevance 0.25 Pain Relevance 0.18
The SPINK1 N34S polymorphism was detected in 5 of 172 (2.9%) patients with chronic pancreatitis, in 4 of 200 (2.0%) patients with sporadic pancreatic adenocarcinoma, in 0 of 36 (0%) of patients with familial pancreatic cancer and in 3 of 177 (1.7%) controls of chronic cholecystitis.
Transcription (detected) of SPINK1 (N34S) associated with adenocarcinoma, pancreatic cancer, cholecystitis and chronic pancreatitis
4) Confidence 0.44 Published 2003 Journal Cancer Biol. Ther. Section Abstract Doc Link 14688470 Disease Relevance 1.27 Pain Relevance 0.34
The SPINK1 N34S mutation was detected by the PCR-RFLP technique.
Transcription (detected) of SPINK1 N34S (N34S)
5) Confidence 0.39 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16187186 Disease Relevance 0.61 Pain Relevance 0.61

General Comments

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