INT115401

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.27
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry1) aging (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
neurons 2
platelet 1
astrocytes 1
microglial cells 1
P2ry1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 50 100.00 Very High Very High Very High
agonist 51 99.98 Very High Very High Very High
tetrodotoxin 5 99.16 Very High Very High Very High
Neuropathic pain 5 90.48 High High
chung model 3 89.04 High High
Nucleus accumbens 59 88.32 High High
adenocard 62 88.12 High High
substance P 4 86.16 High High
Potency 5 85.80 High High
dorsal root ganglion 7 85.36 High High
Disease Link Frequency Relevance Heat
Injury 55 99.00 Very High Very High Very High
Eating Disorder 2 97.76 Very High Very High Very High
Ganglion Cysts 10 93.28 High High
Nociception 2 92.88 High High
Appetite Loss 1 90.80 High High
Neuropathic Pain 12 90.48 High High
Retina Disease 1 89.12 High High
Stab Wounds 6 87.88 High High
Apoptosis 21 84.00 Quite High
Leukemia 2 26.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We disclose the design of a novel series of cyanoguanidines that are potent (IC(50) approximately 10-100 nM) and selective (> or = 100-fold) P2X(7) receptor antagonists against the other P2 receptor subtypes such as the P2Y(2), P2X(4), and P2X(3).
Negative_regulation (antagonists) of P2Y associated with antagonist
1) Confidence 0.42 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19397270 Disease Relevance 0.26 Pain Relevance 0.62
Mucosal touch and distention-induced Ca2+ transients in submucous neurons were reduced by apyrase and prevented by blocking the P2Y1 R with MRS 2179 and TTX; denervation of the mucosa.
Negative_regulation (blocking) of P2Y1 in neurons associated with tetrodotoxin
2) Confidence 0.38 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689471 Disease Relevance 0.09 Pain Relevance 0.76
In such a restricted feeding model for rats the P2Y1 receptor mRNA was initially reduced, possibly related to the aversive or stressor effects of the impaired energy balance [73].
Spec (possibly) Negative_regulation (reduced) of P2Y1 receptor mRNA
3) Confidence 0.37 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0.28 Pain Relevance 0.32
They also showed that ATP and ADP stimulate the migration and differentiation of these progenitor cells and inhibit their mitogenic response to platelet-derived growth factor, thus confirming an important regulatory role for the adeninenucleotide-preferring P2Y1 receptor subtype.
Negative_regulation (preferring) of P2Y1 receptor in platelet
4) Confidence 0.24 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.08 Pain Relevance 0.18
In the stab-wound model, stimulation of P2 receptors with agonists preferring P2Y1 and P2X7 receptor subtypes promoted the morphological changes of resting to activated microglial cells.
Negative_regulation (preferring) of P2Y1 in microglial cells associated with injury and agonist
5) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.55 Pain Relevance 0.16
Although our knowledge of their cell-specific localization at the protein level is still incomplete, it appears that a number of them, such as P2Y1, P2Y2, and P2Y6 receptors, are expressed both on neurons and astrocytes [90–96], whereas others are not exclusively, but predominantly localized to astrocytes (P2Y13: [97] P2Y14: [98]), oligodendrocytes (P2Y12: [99]], or microglia (P2Y12: [100]).
Negative_regulation (number) of P2Y1 in astrocytes
6) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0 Pain Relevance 0.10
Although our knowledge of their cell-specific localization at the protein level is still incomplete, it appears that a number of them, such as P2Y1, P2Y2, and P2Y6 receptors, are expressed both on neurons and astrocytes [90–96], whereas others are not exclusively, but predominantly localized to astrocytes (P2Y13: [97] P2Y14: [98]), oligodendrocytes (P2Y12: [99]], or microglia (P2Y12: [100]).
Negative_regulation (number) of P2Y1 in neurons
7) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0 Pain Relevance 0.10

General Comments

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