INT115423
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Further insight into the mechanisms that underlie MEN1-associated tumourigenesis may provide opportunities for new therapeutic strategies.
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Carcinoid tumours in MEN1 do not release serotonin (5HT), but do produce 5-hydroxytryptophan (5-HTP), the precursor of serotonin. | |||||||||||||||
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MEN1 and CNC syndromes were ruled out given the absence of the characteristic biochemical and clinical features of these syndromes (such as hyperparathyroidism and enteropancreatic tumors for MEN1 and spotty skin pigmentation, cutaneous myxomas and Cushings syndrome for CNC). | |||||||||||||||
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No clinical and biochemical features of the MEN1 and CNC syndromes were observed in this patient. | |||||||||||||||
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Georgitsi et al. studied 91 cases of MEN1-related tumors without MEN1 mutation, and they detected 2 cases (2.2 %) with AIP germline mutations.11 However, no details of the clinical manifestation of the mutated patients were provided, and it is not clear if they were FIPA/IFS patients. | |||||||||||||||
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Because MEN1 and p53 mutations had been previously excluded in this case,16,25 we hypothesized that loss of the AIP gene could be implicated.
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Georgitsi et al. studied 91 cases of MEN1-related tumors without MEN1 mutation, and they detected 2 cases (2.2 %) with AIP germline mutations.11 However, no details of the clinical manifestation of the mutated patients were provided, and it is not clear if they were FIPA/IFS patients. | |||||||||||||||
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MEN1 and CNC syndromes were ruled out given the absence of the characteristic biochemical and clinical features of these syndromes (such as hyperparathyroidism and enteropancreatic tumors for MEN1 and spotty skin pigmentation, cutaneous myxomas and Cushings syndrome for CNC). | |||||||||||||||
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Early works in the area of tumor biology such as the role of p53, bcl-2, bax, MEN1, FGF TGF PDGF and VEGF expression are of interest and need to be explored further. | |||||||||||||||
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General Comments
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