INT115423

Context Info Confidence 0.47 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 9 Disease Relevance 14.08 Pain Relevance 0.64

protein binding, bridging (Men1) embryo development (Men1) DNA binding (Men1) protein complex (Men1) cytoplasm (Men1) cytosol (Men1)

Anatomy Link Frequency germline 2 skin 2 Men1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Serotonin 8 100.00 5HT 2 100.00 Somatostatin 15 88.84 imagery 30 84.24 palliative 1 81.08 Dismenorea 6 66.68 agonist 2 43.24 dopamine receptor 2 42.88 Dopamine 2 38.56 tolerance 2 29.60

Disease Link Frequency Relevance Heat Cancer 267 100.00 Multiple Endocrine Neoplasia Type 1 223 100.00 Syndrome 46 100.00 Carney Complex 30 100.00 Hypercalcemia 14 100.00 Carcinoid 36 99.92 Hodgkin's Disease 48 99.60 Thyroid Neoplasm 14 98.40 Myxoma 6 98.36 Adrenal Cancer 64 97.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further insight into the mechanisms that underlie MEN1-associated tumourigenesis may provide opportunities for new therapeutic strategies.

Gene_expression (underlie) of MEN1 associated with multiple endocrine neoplasia type 1

1) Confidence 0.47 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 1.27 Pain Relevance 0

Carcinoid tumours in MEN1 do not release serotonin (5HT), but do produce 5-hydroxytryptophan (5-HTP), the precursor of serotonin.

Gene_expression (produce) of MEN1 associated with multiple endocrine neoplasia type 1, carcinoid, 5ht and serotonin

2) Confidence 0.47 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.35 Pain Relevance 0.28

MEN1 and CNC syndromes were ruled out given the absence of the characteristic biochemical and clinical features of these syndromes (such as hyperparathyroidism and enteropancreatic tumors for MEN1 and spotty skin pigmentation, cutaneous myxomas and Cushing’s syndrome for CNC).

Gene_expression (syndromes) of MEN1 in skin associated with multiple endocrine neoplasia type 1, myxoma, carney complex, cancer, syndrome and hypercalcemia

3) Confidence 0.27 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.88 Pain Relevance 0

No clinical and biochemical features of the MEN1 and CNC syndromes were observed in this patient.

Gene_expression (syndromes) of MEN1 associated with multiple endocrine neoplasia type 1, carney complex and syndrome

4) Confidence 0.27 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.14 Pain Relevance 0.18

Georgitsi et al. studied 91 cases of “MEN1-related” tumors without MEN1 mutation, and they detected 2 cases (2.2 %) with AIP germline mutations.11 However, no details of the clinical manifestation of the mutated patients were provided, and it is not clear if they were FIPA/IFS patients.

Gene_expression (mutation) of MEN1 in germline associated with multiple endocrine neoplasia type 1, cancer and pituitary cancer

5) Confidence 0.27 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.52 Pain Relevance 0

Because MEN1 and p53 mutations had been previously excluded in this case,16,25 we hypothesized that loss of the AIP gene could be implicated.

Gene_expression (excluded) of MEN1 associated with multiple endocrine neoplasia type 1

6) Confidence 0.27 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.67 Pain Relevance 0

Georgitsi et al. studied 91 cases of “MEN1-related” tumors without MEN1 mutation, and they detected 2 cases (2.2 %) with AIP germline mutations.11 However, no details of the clinical manifestation of the mutated patients were provided, and it is not clear if they were FIPA/IFS patients.

Gene_expression (mutation) of MEN1 in germline associated with multiple endocrine neoplasia type 1, cancer and pituitary cancer

7) Confidence 0.27 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.51 Pain Relevance 0

MEN1 and CNC syndromes were ruled out given the absence of the characteristic biochemical and clinical features of these syndromes (such as hyperparathyroidism and enteropancreatic tumors for MEN1 and spotty skin pigmentation, cutaneous myxomas and Cushing’s syndrome for CNC).

Gene_expression (syndromes) of MEN1 in skin associated with multiple endocrine neoplasia type 1, myxoma, carney complex, cancer, syndrome and hypercalcemia

8) Confidence 0.23 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.71 Pain Relevance 0

Early works in the area of tumor biology such as the role of p53, bcl-2, bax, MEN1, FGF TGF PDGF and VEGF expression are of interest and need to be explored further.

Gene_expression (expression) of MEN1 associated with multiple endocrine neoplasia type 1 and cancer

9) Confidence 0.07 Published 2003 Journal Acta Oncol Section Abstract Doc Link 14690153 Disease Relevance 1.04 Pain Relevance 0.18

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