INT115462

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.35
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) extracellular space (Plau) extracellular region (Plau)
kinase activity (Plau)
Anatomy Link Frequency
extracellular matrix 4
hepatocytes 2
plaque 2
lung 2
MDA-MB-231 2
Plau (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 100.00 Very High Very High Very High
COX-2 inhibitor 10 98.34 Very High Very High Very High
Inflammation 143 77.60 Quite High
Potency 4 69.04 Quite High
cytokine 47 68.08 Quite High
Angina 2 50.00 Quite Low
Kinase C 4 49.24 Quite Low
agonist 17 15.20 Low Low
cINOD 37 5.00 Very Low Very Low Very Low
imagery 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 493 99.98 Very High Very High Very High
Severe Combined Immunodeficiency 14 99.96 Very High Very High Very High
Breast Cancer 185 99.84 Very High Very High Very High
Ovarian Cancer 18 99.16 Very High Very High Very High
Metastasis 189 98.00 Very High Very High Very High
Adenoma 8 92.84 High High
Adhesions 23 90.08 High High
Aggression 2 82.52 Quite High
Apoptosis 29 80.44 Quite High
INFLAMMATION 166 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a mouse mammary cancer model, induced uPA expression delayed tumor progression and had antiangiogenic and antiproliferative effects.
Positive_regulation (induced) of Gene_expression (expression) of uPA associated with cancer
1) Confidence 0.65 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.58 Pain Relevance 0
Tumors expressing proteolytically inactive uPA mutants grew faster than tumors overexpressing proteolytically active uPA, suggesting that the inhibitory actions were mediated by uPA's protease activity [8].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of uPA associated with cancer
2) Confidence 0.65 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.50 Pain Relevance 0
We carried out experiments to investigate whether the COX-2 inhibitor celecoxib at a dose of either 200 mg bid or 400 mg bid could significantly affect endogenous uPA, PAI-1 or PGE2 production in women at increased risk for breast cancer.
Positive_regulation (endogenous) of Gene_expression (production) of uPA associated with breast cancer and cox-2 inhibitor
3) Confidence 0.47 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.17 Pain Relevance 0.05
uPA levels in postmenopausal women increase, while PAI-1 and PGE2 decrease, after treatment with high dose celecoxib
Positive_regulation (while) of Gene_expression (levels) of uPA
4) Confidence 0.47 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
uPA levels in postmenopausal women increase, while PAI-1 and PGE2 decrease, after treatment with high dose celecoxib
Positive_regulation (increase) of Gene_expression (levels) of uPA
5) Confidence 0.47 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor growth and prolong survival.
Positive_regulation (overexpression) of Gene_expression (overexpression) of uPA associated with cancer and breast cancer
6) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2580770 Disease Relevance 0.43 Pain Relevance 0
While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor growth and prolong survival.
Positive_regulation (increased) of Gene_expression (expression) of uPA associated with cancer and breast cancer
7) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2580770 Disease Relevance 0.41 Pain Relevance 0
It has been shown that PAs generate endogenous angiogenesis inhibitors, and mice with tumors that overexpressed uPA demonstrated tumor growth inhibition, fewer lung metastases and prolonged survival compared to controls [8].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of uPA in lung associated with cancer and metastasis
8) Confidence 0.38 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.60 Pain Relevance 0
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Positive_regulation (elevated) of Gene_expression (expression) of urokinase-type plasminogen activator in extracellular matrix associated with metalloproteinase
9) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.11
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Positive_regulation (elevated) of Gene_expression (expression) of Plau in extracellular matrix associated with metalloproteinase
10) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.11
Neither rifampicin nor 3-MC induced the expression of any of the six h-CYPs in miceAlb-uPA/SCID that had not been transplanted with h-hepatocytes.
Neg (Neither) Positive_regulation (induced) of Gene_expression (expression) of uPA in hepatocytes associated with severe combined immunodeficiency
11) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.10 Pain Relevance 0.03
Loss of TTP is observed in the highly metastatic breast tumor line, MDA-MB-231, that is functionally associated with increased invasion and elevated expression of uPA and uPAR mRNAs due to their stabilization [162].
Positive_regulation (elevated) of Gene_expression (expression) of uPA in MDA-MB-231 associated with breast cancer
12) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.83 Pain Relevance 0.13
LPA-induced uPA production promotes invasion by several ovarian cancer cell lines (Pustilnik et al., 1999; Gil et al., 2008). uPA levels carry a prognostic value in ovarian cancer and correlate with poor prognosis (Schmalfeldt et al., 2001; Murthi et al., 2004).
Positive_regulation (promotes) of Gene_expression (production) of uPA associated with ovarian cancer
13) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.87 Pain Relevance 0.09
Increased plasma levels of u-PA were associated with plaque rupture (3.0 +/- 0.7 vs 2.5 +/- 0.9 ng/mL, P =.062).
Positive_regulation (Increased) of Gene_expression (levels) of u-PA in plaque
14) Confidence 0.01 Published 2004 Journal Am. Heart J. Section Body Doc Link 14691435 Disease Relevance 0 Pain Relevance 0

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