INT115471

Context Info Confidence 0.36 First Reported 2004 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 4.06 Pain Relevance 0.94

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele) cellular_component (Sele)

Anatomy Link Frequency plasma 2 leukocyte 1 endothelial cells 1 Sele (Rattus norvegicus) Sele - S128R (1)

Pain Link Frequency Relevance Heat Inflammation 10 97.92 ischemia 82 94.72 Restless leg syndrome 2 88.64 cINOD 1 83.92 Inflammatory marker 2 50.00 cva 3 5.00 corticosteroid 2 5.00 anesthesia 2 5.00 halothane 2 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Adhesions 18 100.00 Cardiovascular Disease 14 99.24 Cancer 9 98.04 INFLAMMATION 9 97.92 Cv Unclassified Under Development 82 94.72 Injury 5 94.24 Peripheral Arterial Disease 4 91.04 Increased Venous Pressure Under Development 4 88.64 Acute Renal Failure 2 86.56 Immunotherapy Of Cancer 1 81.76

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, we investigated the association between the E-Selectin Ser128Arg genotype, E-Selectin plasma levels and restenosis after femoropopliteal PTA.

E-Selectin Binding (association) of in plasma associated with cardiovascular disease

1) Confidence 0.36 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 14691583 Disease Relevance 0.76 Pain Relevance 0.17

Therefore, we investigated the association between the E-Selectin Ser128Arg genotype, E-Selectin plasma levels and restenosis after femoropopliteal PTA.

E-Selectin (S128R) Binding (association) of in plasma associated with cardiovascular disease

2) Confidence 0.36 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 14691583 Disease Relevance 0.75 Pain Relevance 0.17

NO modulates leukocyte adhesion in the microcirculation by decreasing the binding of PMN to the adhesion molecules E-selectin and ICAM-1 [22,24].

E-selectin Binding (binding) of in leukocyte associated with adhesions

3) Confidence 0.16 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 1.05 Pain Relevance 0.34

CONCLUSIONS: Interleukin-6 was greater in acute myocardial infarction than in unstable angina; E-selectin was positively associated with a previous myocardial infarction and inversely related to age.

E-selectin Binding (associated) of

4) Confidence 0.03 Published 2005 Journal Coron. Artery Dis. Section Body Doc Link 16205449 Disease Relevance 0 Pain Relevance 0

The most studied ligands for CAMs expressed on cancer cells, sialyl Lewis (a/x) antigens, are shown to be involved in adhesion to endothelial cells by binding to E-selectin.

E-selectin Binding (binding) of in endothelial cells associated with cancer and adhesions

5) Confidence 0.03 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17305540 Disease Relevance 1.51 Pain Relevance 0.27

General Comments

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