INT115494

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
chondrocytes 2
DRG 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 80 98.70 Very High Very High Very High
qutenza 1 95.96 Very High Very High Very High
licofelone 39 94.92 High High
cytokine 3 51.04 Quite High
metalloproteinase 10 22.72 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 9 99.00 Very High Very High Very High
Osteoarthritis 80 98.70 Very High Very High Very High
Necrosis 1 52.36 Quite High
Cancer 1 52.00 Quite High
Disease 6 33.28 Quite Low
Arthritis 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Stab Wounds 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induced MMP-13 in OA chondrocytes, and that this effect is mediated by the selective inhibition of the activation of the p38 pathway and the downstream transcription factor cyclic-AMP responsive element binding protein (CREB) [23].
Negative_regulation (inhibition) of Positive_regulation (activation) of CREB in chondrocytes associated with osteoarthritis
1) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257437 Disease Relevance 0.65 Pain Relevance 0.73
Resiniferatoxin reduced CYP-induced up-regulation of p-CREB in DRG, suggesting that cystitis can reveal an altered CREB phosphorylation that may be mediated by capsaicin-sensitive bladder afferents.
Negative_regulation (reduced) of Positive_regulation (up-regulation) of CREB in DRG associated with qutenza and cystitis
2) Confidence 0.04 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14694538 Disease Relevance 0.60 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox