INT1155

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Context Info
Confidence 0.36
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.64
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
smooth muscle 2
nerve 1
muscle 1
nucleus 1
stomach 1
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 59 100.00 Very High Very High Very High
substance P 3 98.80 Very High Very High Very High
Enkephalin 3 98.12 Very High Very High Very High
Neuropeptide 45 98.08 Very High Very High Very High
Morphine 2 97.08 Very High Very High Very High
peptic ulcer disease 3 95.24 Very High Very High Very High
chemokine 35 93.52 High High
agonist 12 88.32 High High
Pain 6 86.44 High High
bradykinin 2 74.16 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 99.88 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.96 Very High Very High Very High
Abscess 2 97.68 Very High Very High Very High
Ulcers 5 95.24 Very High Very High Very High
Pyogenic Liver Abscess 5 95.12 Very High Very High Very High
Disease 31 94.72 High High
Infection 3 93.72 High High
Osteomyelitis 1 89.04 High High
Pain 6 86.44 High High
Fever 2 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gas formation occurs as a result of mixed acid fermentation within the abscess by formic hydrogenlyase, an enzyme produced by certain bacteria.
Gas Binding (formation) of associated with abscess
1) Confidence 0.36 Published 2008 Journal Singapore Med J Section Abstract Doc Link 18465035 Disease Relevance 1.14 Pain Relevance 0.05
Partially purified nerve varicosities prepared from canine small intestinal myenteric, deep muscular and submucosal plexuses were found to contain, by radioimmunoassay, gastrin-releasing polypeptide (GRP), substance P, Leu-enkephalin, Met-enkephalin, vasoactive intestinal polypeptide (VIP) and neurokinin A, but did not contain detectable amounts of neurokinin B.
gastrin Binding (contain) of in nerve associated with enkephalin, increased venous pressure under development and substance p
2) Confidence 0.36 Published 1990 Journal Peptides Section Abstract Doc Link 2342994 Disease Relevance 0.17 Pain Relevance 0.39
Physiologic recognition of the roles of vagal stimulation and antral gastrin in the secretion of acid from the stomach resulted in the development of the operation of vagotomy and antrectomy for peptic ulcer disease.
gastrin Binding (recognition) of in stomach associated with peptic ulcer disease and disease
3) Confidence 0.35 Published 1990 Journal Surg Gynecol Obstet Section Abstract Doc Link 2152987 Disease Relevance 0.55 Pain Relevance 0.23
Gas formation was present in 5 of the 12 patients recorded, and 4 of them died during hospitalization.
Gas Binding (formation) of
4) Confidence 0.35 Published 2001 Journal J Microbiol Immunol Infect Section Abstract Doc Link 11605812 Disease Relevance 1.19 Pain Relevance 0.09
Cholecystokinin (CCK) is structurally closely related to gastrin and shares high affinity for CCK-B/gastrin receptors.
gastrin Binding (affinity) of associated with cholecystokinin
5) Confidence 0.33 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.08 Pain Relevance 0.42
The purpose of this study were 1) to quantify the lower esophageal sphincter (LES) response to intravenous cholecystokinin (CCK) in both man and the opossum in vivo, 2) to characterize the interaction of CCK and gastrin on circular muscle of the LES, and 3) to determine the site of action of CCK on LES muscle.
gastrin Binding (interaction) of in muscle associated with cholecystokinin
6) Confidence 0.29 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 165733 Disease Relevance 0 Pain Relevance 0.57
This study compared the actions and interactions of human synthetic gastrin, octapeptide-cholecystokinin (OP-CCK), cholecystokinin (CCK), and secretin on the amplitude of isometric tension developed in strips of dog antral smooth muscle in vitro.
gastrin Binding (interactions) of in smooth muscle associated with cholecystokinin
7) Confidence 0.24 Published 1979 Journal Am. J. Physiol. Section Abstract Doc Link 434148 Disease Relevance 0 Pain Relevance 0.36
Interaction between gastrin, CCK, and secretin on canine antral smooth muscle in vitro.
gastrin Binding (Interaction) of in smooth muscle
8) Confidence 0.24 Published 1979 Journal Am. J. Physiol. Section Title Doc Link 434148 Disease Relevance 0 Pain Relevance 0.50
Cluster 8 consists of peptide receptors with known ligands such as gastrin (GAS), cholecystokinin (CCK), orexin (OXR) and neuropeptide FF (NFF) or morphine modulating peptides.
gastrin Binding (ligands) of associated with neuropeptide, cholecystokinin and morphine
9) Confidence 0.09 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.40
They share many conserved amino acids, known to be important for high affinity binding of gastrin-releasing peptide (GRP) and bombesin to GRPR and NMB binding to NMB-R [29-31] (Figure 2).
gastrin Binding (affinity) of
10) Confidence 0.09 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.29
The phosphorylated STAT1 forms homodimers that translocate to the nucleus and bind GAS (IFN-?
GAS Binding (bind) of in nucleus
11) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.51 Pain Relevance 0
The CCKB receptor is a good example of this phenomenon, as truncation of its N-terminus reduces its affinity for both gastrin and CCK-8 (Miyake, 1995).
gastrin Binding (affinity) of
12) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0 Pain Relevance 0.21

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