INT115501

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.56
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TGM2) plasma membrane (TGM2) transferase activity, transferring acyl groups (TGM2)
cytoplasm (TGM2)
Anatomy Link Frequency
B cells 1
Dendritic cells 1
fibroblasts 1
brush 1
TGM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 99.04 Very High Very High Very High
withdrawal 4 79.80 Quite High
Inflammation 77 67.56 Quite High
fibrosis 1 64.12 Quite High
Chronic pancreatitis 1 50.00 Quite Low
Potency 3 39.84 Quite Low
Inflammatory response 12 19.36 Low Low
cytokine 35 7.44 Low Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 174 99.36 Very High Very High Very High
Pancreatic Cancer 9 97.84 Very High Very High Very High
Glaucoma 7 96.80 Very High Very High Very High
Disease 201 95.80 Very High Very High Very High
Adhesions 39 95.68 Very High Very High Very High
Cicatrix 5 95.40 Very High Very High Very High
Wound Healing 1 92.32 High High
Cancer 61 85.68 High High
Syndrome 1 85.60 High High
Blister 11 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The list of correspondingly important up-regulated genes in NHEK was extensive and included activin A, transglutaminase 2 (TGM2), ErbB3 (HER3), matrix metalloproteinase 9 (MMP-9), fibronectin (FN!)
Gene_expression (included) of transglutaminase 2 associated with metalloproteinase
1) Confidence 0.64 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0.12
The list of correspondingly important up-regulated genes in NHEK was extensive and included activin A, transglutaminase 2 (TGM2), ErbB3 (HER3), matrix metalloproteinase 9 (MMP-9), fibronectin (FN!)
Gene_expression (included) of TGM2 associated with metalloproteinase
2) Confidence 0.64 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0.12
Dendritic cells present in the lamina propria express both surface TG2 and HLA DQ molecules [121], and can extend dendrites through the epithelial layer to directly sample luminal antigens [122].
Gene_expression (express) of TG2 in Dendritic cells
3) Confidence 0.56 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.35 Pain Relevance 0
Since TG2 forms covalent complexes with gluten peptides [139], it has been proposed that intestinal gluten-reactive T cells can provide co-stimulation to B cells expressing TG2-specific antibodies as part of an autoimmune humoral response [140].
Gene_expression (expressing) of TG2-specific in B cells
4) Confidence 0.56 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.72 Pain Relevance 0
Among the most differentially expressed genes identified by PCA were Mesothelin, Muc4, Muc5A/C, Kallikrein 10, Transglutaminase 2, Fascin, TMPRSS3 and stratifin.
Gene_expression (expressed) of Transglutaminase 2
5) Confidence 0.51 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14695172 Disease Relevance 0.81 Pain Relevance 0
Although TG2 is found in the lamina propria and the brush border of enterocytes, the precise location and context in which TG2 encounters and deamidates gluten peptides is not yet known.


Gene_expression (found) of TG2 in brush
6) Confidence 0.49 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.86 Pain Relevance 0
Tissue transglutaminase and F XIIIa are expressed on the surface of monocytic cells and some evidence indicates the involvement of transglutaminases in cell adhesion, for example, they can influence adhesion of monocytic cells on fibronectin [33].
Gene_expression (expressed) of Tissue transglutaminase associated with adhesions
7) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550842 Disease Relevance 0.84 Pain Relevance 0
2 may be essential for the expression and activity of tissue transglutaminase in subconjunctival fibroblasts.
Gene_expression (expression) of tissue transglutaminase in fibroblasts
8) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2763124 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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