INT115515

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.76
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS2) extracellular space (PRSS2) extracellular region (PRSS2)
PRSS2 (Homo sapiens)
PRSS2 - E79K (1)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 18 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 40 100.00 Very High Very High Very High
Pancreatic Cancer 38 99.74 Very High Very High Very High
Disease 5 91.96 High High
Choledocholithiasis 8 89.60 High High
Autolysis 3 82.08 Quite High
Cancer 2 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).
Positive_regulation (transactivation) of trypsinogen (E79K) associated with pancreatitis
1) Confidence 0.69 Published 2004 Journal Hum. Mutat. Section Title Doc Link 14695529 Disease Relevance 0.46 Pain Relevance 0.09
Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).
Positive_regulation (transactivation) of PRSS2 associated with pancreatitis
2) Confidence 0.69 Published 2004 Journal Hum. Mutat. Section Title Doc Link 14695529 Disease Relevance 0.46 Pain Relevance 0.09
The observations not only suggest a novel mechanism of action for pancreatitis-associated trypsinogen mutations, but also highlight the importance of interactions between the two major trypsinogen isoforms in the development of genetically determined chronic pancreatitis.
Positive_regulation (pancreatitis-associated) of trypsinogen associated with pancreatitis and chronic pancreatitis
3) Confidence 0.50 Published 2004 Journal Hum. Mutat. Section Abstract Doc Link 14695529 Disease Relevance 0.72 Pain Relevance 0.09
These alterations increased the copy number of PRSS1 as well as PRSS2, which encodes anionic trypsinogen.
Positive_regulation (increased) of PRSS2
4) Confidence 0.37 Published 2008 Journal Cytogenet. Genome Res. Section Abstract Doc Link 19287144 Disease Relevance 0.55 Pain Relevance 0.31
Elevated PRSS2 mRNA levels correlated with high T stage.
Positive_regulation (Elevated) of PRSS2 mRNA
5) Confidence 0.35 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20428826 Disease Relevance 1.62 Pain Relevance 0.24
In all PC cell lines, PRSS 2 mRNA levels were elevated, while PLRP 1 mRNA was detected in 4/5 cell lines.
Positive_regulation (elevated) of PRSS 2 mRNA associated with pancreatic cancer
6) Confidence 0.35 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20428826 Disease Relevance 1.95 Pain Relevance 0.30

General Comments

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