INT115522

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2) plasma membrane (Itgb2)
Itgb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 5 99.48 Very High Very High Very High
cINOD 1 98.72 Very High Very High Very High
Opioid 4 50.00 Quite Low
IPN 2 50.00 Quite Low
cva 2 15.20 Low Low
Pain 2 10.00 Low Low
chemokine 1 10.00 Low Low
ischemia 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.48 Very High Very High Very High
Stroke 57 77.44 Quite High
Middle Cerebral Artery Infarction 31 61.88 Quite High
Inflammatory Pain 2 50.00 Quite Low
Death 3 48.28 Quite Low
Hemorrhage 1 15.20 Low Low
Pressure And Volume Under Development 2 13.44 Low Low
Injury 6 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Top regulated genes include TIMP3 (+2.39 fold), ITGB2 (+1.21 fold), COL17A1 (+1.27 fold), GZMB (+1.74 fold), JAG1 (-2.09 fold), CSF-1 (-1.70 fold), SLP1 (-1.70 fold), FCGR2B (-1.51 fold), and PIK3CD (-1.31 fold).



Regulation (regulated) of ITGB2
1) Confidence 0.19 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.33 Pain Relevance 0
Mobilized PMN had decreased content of beta-endorphin but not of Met-enkephalin per cell, down-regulation of CD62L, up-regulation of CD49d (but no change in CD18), and reduced migration toward higher chemokine concentrations (all P < 0.05).
Neg (no) Regulation (change) of CD18
2) Confidence 0.17 Published 2004 Journal Anesthesiology Section Body Doc Link 14695736 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To elucidate the effect of piroxicam beta-cyclodextrin (PbetaCD), a non-steroidal anti-inflammatory drug (NSAID), on the efficacy of the intrauterine device (IUD) in a rat model.
Regulation (effect) of PbetaCD associated with inflammation and cinod
3) Confidence 0.09 Published 2007 Journal Eur J Contracept Reprod Health Care Section Abstract Doc Link 17559007 Disease Relevance 0.10 Pain Relevance 0.15

General Comments

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