INT115528

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 22.96
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
neuronal 2
urinary bladder 1
spinal nerve 1
retina 1
brain 1
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 100.00 Very High Very High Very High
Spinal nerve ligature 1 100.00 Very High Very High Very High
Inflammation 166 99.90 Very High Very High Very High
qutenza 25 99.58 Very High Very High Very High
Paracetamol 249 98.98 Very High Very High Very High
Arthritis 102 98.68 Very High Very High Very High
Dorsal horn neuron 3 97.12 Very High Very High Very High
Glutamate 37 96.82 Very High Very High Very High
Inflammatory response 12 96.64 Very High Very High Very High
Potency 2 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pneumonia 3 99.90 Very High Very High Very High
Diabetes Mellitus 168 99.84 Very High Very High Very High
Alzheimer's Dementia 24 99.78 Very High Very High Very High
Insulin Resistance 44 99.76 Very High Very High Very High
INFLAMMATION 199 99.52 Very High Very High Very High
Injury 126 99.48 Very High Very High Very High
Hyperglycemia 25 99.48 Very High Very High Very High
Obesity 117 99.28 Very High Very High Very High
Neuropathic Pain 5 99.22 Very High Very High Very High
Overdose 15 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore considered desirable to examine the feasibility of preventing cataract formation by oxyradical scavengers that are more stable, even when incorporated in eye drop preparations and their reaction products generated by reacting with ROS are also not toxic.
ROS Binding (reacting) of in eye associated with cataract
1) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3002968 Disease Relevance 0.36 Pain Relevance 0
Its reaction with ROS is accompanied with the formation of its 8-hydroxy derivative [35-37], with structure similar to urate, another ROS scavenger.
ROS Binding (reaction) of
2) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3002968 Disease Relevance 0.47 Pain Relevance 0
Neuropathic rats were produced by L5 spinal nerve ligation and mitochondrial ROS was detected by the mitochondrial marker, Mitotracker Red CM-H(2)XRos (MT-Red).
ROS Binding (ligation) of in spinal nerve associated with spinal nerve ligature and neuropathic pain
3) Confidence 0.26 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16183198 Disease Relevance 0.53 Pain Relevance 0.39
Low concentrations of capsaicin like CoQ1 inhibited ROS formation but CoQ1 was more effective at restoring the mitochondrial membrane potential collapse caused by complex 1 inhibitors such as rotenone.
ROS Binding (formation) of associated with qutenza and shock
4) Confidence 0.23 Published 2003 Journal Biofactors Section Abstract Doc Link 14695935 Disease Relevance 0.32 Pain Relevance 0.38
Immediately after reperfusion, however, an excessive degree of ROS generation and the activation of MAP kinase might be involved.
ROS Binding (generation) of
5) Confidence 0.20 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.04 Pain Relevance 0.12
It was originally believed that ROS formation occurs primarily, or even exclusively, during reperfusion, when oxygen interacts with the damaged mitochondrial respiratory chain.
ROS Binding (formation) of in respiratory
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693933 Disease Relevance 0.59 Pain Relevance 0.08
At low concentrations, capsaicin acts as a CoQ mimic by protecting against rotenone induced ROS formation and mitochondrial membrane potential collapse.
ROS Binding (formation) of associated with qutenza and shock
7) Confidence 0.16 Published 2003 Journal Biofactors Section Abstract Doc Link 14695935 Disease Relevance 0.35 Pain Relevance 0.67
Based on the observed association between reduced ROS and increased susceptibility to arthritis, the researchers wanted to find out whether treatment with a compound that increases ROS production by the NADPH oxidase complex would cause an improvement in arthritis.


ROS Binding (association) of associated with arthritis
8) Confidence 0.14 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 1.41 Pain Relevance 0.57
The present study, for the first time, demonstrated the anti-oxidative effects possessed by the water extract of the biennial flower of Panax notoginseng through the suppression of H2O2-induced ROS formation and neuroprotection against H2O2 insult.
ROS Binding (formation) of
9) Confidence 0.12 Published 2010 Journal Chin Med Section Body Doc Link PMC2978211 Disease Relevance 0 Pain Relevance 0
To test whether impaired vasodilation in arteries from HSD and HFD is due to an interaction of ROS and NO, vessels from each group were incubated in the presence of both the NOS inhibitor LNNA and the ROS scavengers tiron and catalase or EUK-134.
ROS Binding (interaction) of in vessels associated with increased venous pressure under development
10) Confidence 0.11 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.91 Pain Relevance 0.07
ROS activate p38 kinase, which further promotes ROS generation, forming a positive feedback loop to sustain ROS-p38 kinase signaling, which may associate with a reduction in SIRT1 protein expression.
ROS Binding (generation) of
11) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.68 Pain Relevance 0.12
OBJECTIVES: To investigate the effects of reactive oxygen species (ROS) on the micturition reflex in vivo, especially in bladder afferent signalling in rats, as several pathophysiological conditions in the urinary bladder (e.g. ischaemia/reperfusion and inflammation) are characterized by the formation of ROS.
ROS Binding (formation) of in urinary bladder associated with inflammation, cv unclassified under development and overactive bladder
12) Confidence 0.10 Published 2008 Journal BJU Int. Section Abstract Doc Link 18005207 Disease Relevance 0.37 Pain Relevance 0.05
We and others have demonstrated that increased ROS is associated with aldosterone-mediated cardio, renal, and vascular damage in rats (7-10).
ROS Binding (associated) of
13) Confidence 0.08 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.80 Pain Relevance 0.08
These results suggest that ROS generation, through decreasing GSH levels, plays a key role in the mechanism by which AAP induces rat cortical neuronal death.
ROS Binding (generation) of in neuronal associated with paracetamol and death
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.45 Pain Relevance 1.03
Phenolic compounds have a high reactivity towards lipid peroxyl radicals and are thus able to interact with ROS to interrupt the propagation of lipid peroxidation [40].
ROS Binding (interact) of
15) Confidence 0.08 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1192789 Disease Relevance 0.08 Pain Relevance 0.04
In the control SD rat retina, 334Ser and 338Ser antibody specifically recognized rod outer segments (ROS) of light-adapted but not of dark-adapted retina, and its immunopositivities were then gradually diminished from base to tip of ROS following dark adaptation as described previously (Ohguro et al 2003) (data not shown).
ROS Binding (recognized) of in retina
16) Confidence 0.08 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.23 Pain Relevance 0
Anyhow, and as part of the complex net of interactions present in this animal model, the increased formation of ROS also contributes to fructose-induced hypertension.


ROS Binding (formation) of associated with pressure and volume under development
17) Confidence 0.07 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2974659 Disease Relevance 1.11 Pain Relevance 0
In addition, we looked for a sign of ROS formation by visualizing oxidized DNA.
ROS Binding (formation) of
18) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900204 Disease Relevance 0.42 Pain Relevance 0
Plausible reasons for the decreased hippurate could be the binding of DOX to the inner mitochondria membrane resulting in mitochondrial lesions and reduction of the synthesis of hippuric acid (Goormaghtigh et al. 1990), or the effects of DOX induced reactive oxygen species (ROS) on mitochondria(Berthiaume and Wallace 2007).
ROS Binding (binding) of
19) Confidence 0.06 Published 2009 Journal Metabolomics Section Body Doc Link PMC2794350 Disease Relevance 0.63 Pain Relevance 0
Retention of ATP and suppression of ROS generation by Ndi1 in RGC-5 cell line
ROS Binding (generation) of
20) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900204 Disease Relevance 0.61 Pain Relevance 0

General Comments

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