INT11553

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Context Info
Confidence 0.03
First Reported 1986
Last Reported 1992
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 1.10
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CCBE1)
Anatomy Link Frequency
CSF 3
plasma 1
CCBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 8 99.98 Very High Very High Very High
cva 4 96.04 Very High Very High Very High
Analgesic 1 93.00 High High
agonist 2 91.88 High High
Neuropeptide 2 90.08 High High
anesthesia 1 75.00 Quite High
epidural 1 54.80 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1 96.04 Very High Very High Very High
Rupture 2 93.24 High High
Cerebral Aneurysm 1 92.20 High High
Aneurism 1 87.44 High High
Lumbar Puncture Related Headaches 5 86.76 High High
Cv General 4 Under Development 2 84.92 Quite High
Subarachnoid Hemorrhage 1 75.00 Quite High
Vascular Malformations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possibility that the intravenous infusion of acetorphan, a prodrug of thiorphan (26 micrograms/kg per min for 60 min), can inhibit plasma and cerebrospinal fluid (CSF) enkephalinase in man in vivo was investigated.
Negative_regulation (inhibit) of cerebrospinal fluid in CSF
1) Confidence 0.03 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3015640 Disease Relevance 0 Pain Relevance 0.09
Loss of cerebrospinal fluid (CSF) from the puncture site with a subsequent decrease in CSF pressure and an increase in transmural wall tension of the vessels might be predisposing factors for the rupture of a pre-existing cerebral aneurysm.
Negative_regulation (Loss) of cerebrospinal fluid in CSF associated with cerebral aneurysm and rupture
2) Confidence 0.03 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1570889 Disease Relevance 0.77 Pain Relevance 0.27
Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans.
Negative_regulation (decreases) of cerebrospinal fluid in cerebrospinal fluid associated with clonidine
3) Confidence 0.01 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.44
Clonidine decreases plasma and cerebrospinal fluid arginine vasopressin but not oxytocin in humans.
Negative_regulation (decreases) of cerebrospinal fluid in plasma associated with clonidine
4) Confidence 0.00 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.44

General Comments

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