INT115532

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
endothelial cells 2
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 1 99.74 Very High Very High Very High
Central nervous system 3 85.88 High High
cINOD 2 67.08 Quite High
aspirin 2 65.44 Quite High
diclofenac 2 64.96 Quite High
cytokine 3 62.84 Quite High
monoamine 13 59.48 Quite High
Pain 2 58.96 Quite High
Nerve growth factor 3 51.92 Quite High
Pyramidal cell 3 24.76 Low Low
Disease Link Frequency Relevance Heat
Metastasis 7 97.12 Very High Very High Very High
Cancer 47 97.00 Very High Very High Very High
Apoptosis 3 92.08 High High
Targeted Disruption 113 92.00 High High
Squamous Cell Carcinoma 1 88.40 High High
Pancreatic Cancer 57 88.32 High High
Schizophrenia 13 71.72 Quite High
INFLAMMATION 1 66.88 Quite High
Pain 2 58.96 Quite High
Congenital Anomalies 10 58.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our results, a previous study (using the same line of mice with loxP-flanked Hb-egf cDNA) demonstrated that a mutation of the Hb-egf gene was associated with decreases in the activation of EGF receptor and ERK [49].
Negative_regulation (decreases) of Positive_regulation (activation) of EGF
1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.28 Pain Relevance 0.10
EGF-R activation was significantly blocked by therapy with PKI 166 and was associated with a significant decrease in tumour cell production of VEGF and IL-8, which correlated with a significant reduction in angiogenesis, and an increase in apoptotic tumour and endothelial cells [49-51].
Negative_regulation (blocked) of Positive_regulation (activation) of EGF-R in endothelial cells associated with cancer and apoptosis
2) Confidence 0.17 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.94 Pain Relevance 0.11
3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 production.
Negative_regulation (inhibition) of Positive_regulation (induced) of epidermal growth factor associated with cox2
3) Confidence 0.05 Published 2004 Journal Int. J. Cancer Section Title Doc Link 14696113 Disease Relevance 0.16 Pain Relevance 0.31

General Comments

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