INT11554

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 129
Total Number 133
Disease Relevance 108.55
Pain Relevance 29.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 17
plasma 15
blood 5
brain 3
granulocyte 3
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 240 100.00 Very High Very High Very High
Dopamine 150 100.00 Very High Very High Very High
metalloproteinase 148 100.00 Very High Very High Very High
COX-2 inhibitor 75 100.00 Very High Very High Very High
Serotonin 41 100.00 Very High Very High Very High
Inflammation 736 99.96 Very High Very High Very High
Multiple sclerosis 357 99.84 Very High Very High Very High
Morphine 23 99.82 Very High Very High Very High
chemokine 74 99.74 Very High Very High Very High
Inflammatory response 68 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 3052 100.00 Very High Very High Very High
Parkinson's Disease 1732 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1693 100.00 Very High Very High Very High
Dementia 829 100.00 Very High Very High Very High
Brain Tumor 11 100.00 Very High Very High Very High
INFLAMMATION 829 99.96 Very High Very High Very High
Leukocytosis 299 99.96 Very High Very High Very High
Lyme Neuroborreliosis 212 99.86 Very High Very High Very High
Motor Neuron Diseases 606 99.84 Very High Very High Very High
Demyelinating Disease 537 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparing the results obtained in PD and dominant OPCA, we suggest that the decrease of CSF HVA in the latter group might not reflect nigrostriatal degeneration as we previously thought.
Negative_regulation (decrease) of CSF HVA in CSF associated with olivopontocerebellar atrophies and disease
1) Confidence 0.59 Published 1993 Journal Bol Estud Med Biol Section Abstract Doc Link 7521168 Disease Relevance 0.77 Pain Relevance 0.36
However, incorporating a model of transitory CSF infection, suppression of systemic infection would also lower the infection rate of trafficking lymphocytes and virus-induced activation, thereby reducing the influx of these cells and rapidly decreasing the CSF VL.
Negative_regulation (decreasing) of CSF in lymphocytes associated with infection
2) Confidence 0.57 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.33 Pain Relevance 0.16
Finally, 5 out of 7 (71%) AIDS patients with cryptococcal meningitis showed a decline in CSF beta 2-M level well related to the decrease of cryptococcal antigen (Crypto-Ag) titres and the clinical remission.
Negative_regulation (decline) of CSF beta 2-M in CSF associated with cryptococcal meningitis and acquired immune deficiency syndrome or hiv infection
3) Confidence 0.55 Published 1992 Journal J Clin Lab Immunol Section Abstract Doc Link 11270518 Disease Relevance 1.48 Pain Relevance 0.26
When a person is upright, the brain is kept afloat by the buoyant action of the CSF in conjunction with the anchoring effects of the vascular structures in the cranium; if the buoyant action of the CSF is decreased i.e. when the CSF volume is decreased, the burden on the vascular structures increases resulting in traction and distortion [5].
Negative_regulation (decreased) of CSF in cranium
4) Confidence 0.50 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1851975 Disease Relevance 1.26 Pain Relevance 0.47
The mean peak serum lidocaine concentration was found 25 minutes after injection, and the corresponding peak CSF level occurred after 70 min.
Negative_regulation (occurred) of CSF in CSF associated with lidocaine
5) Confidence 0.43 Published 1983 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6662163 Disease Relevance 0.09 Pain Relevance 0.74
A recent study conducted on PD subjects found a 40% decrease of hypocretin-1 in the prefrontal cortex and a 25% decrease in the ventricular CSF when compared to controls [122].
Negative_regulation (decrease) of CSF in cortex associated with disease
6) Confidence 0.42 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.33 Pain Relevance 0.30
Thus, the CSF decrease of A?
Negative_regulation (decrease) of CSF
7) Confidence 0.42 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.30 Pain Relevance 0.03
It is at this pressure that the vasodilatation compensation for CSF depletion is no longer sufficient, and thus the symptoms of CSF hypovolaemia become apparent [18].
Negative_regulation (depletion) of CSF associated with pressure volume 2 under development and increased venous pressure under development
8) Confidence 0.42 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1851975 Disease Relevance 0.57 Pain Relevance 0.14
In addition to the disproportionate CSF HIV response, CSF WBC counts were also suppressed in these subjects.
Negative_regulation (suppressed) of CSF associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.41 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.43 Pain Relevance 0
However, his general condition gradually worsened, and a high serum level of G-CSF persisted.
Negative_regulation (persisted) of G-CSF
10) Confidence 0.41 Published 2007 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 17283419 Disease Relevance 0.61 Pain Relevance 0.09
A recent study reported a significant reduction in CSF cystatin C levels in ALS patients relative to polyneuropathy patients [16].
Negative_regulation (reduction) of CSF associated with neuropathy and motor neuron diseases
11) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.99 Pain Relevance 0
However, treatment with non-steroidal anti-inflammatory agents (NSAIDs) may affect reported CSF concentrations: G-CSF levels were significantly lower in samples from subjects not taking NSAIDs.
Negative_regulation (lower) of G-CSF associated with inflammation and cinod
12) Confidence 0.39 Published 1995 Journal Rheumatol. Int. Section Abstract Doc Link 7536953 Disease Relevance 0.69 Pain Relevance 0.63
The random blood glucose (RBG) was normal (5.2 mml/l) and the CSF to blood glucose ratio was reduced (< 0.5).
Negative_regulation (reduced) of CSF in blood
13) Confidence 0.38 Published 2008 Journal Cases J Section Body Doc Link PMC2559826 Disease Relevance 0.96 Pain Relevance 0
The CNS contribution to CSF free MHPG also decreased (as estimated from the differential reductions in CSF and plasma levels).
Negative_regulation (reductions) of CSF in plasma
14) Confidence 0.38 Published 1984 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6199153 Disease Relevance 0.09 Pain Relevance 0.45
Percent reductions in CSF and plasma NE were substantially greater than those for MHPG, suggesting diminished CNS and peripheral NE release and turnover.
Negative_regulation (reductions) of CSF in plasma
15) Confidence 0.38 Published 1984 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6199153 Disease Relevance 0.09 Pain Relevance 0.50
The least loss of CSF occurred with the 26-gauge Atraucan needle.
Negative_regulation (loss) of CSF in CSF
16) Confidence 0.38 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9842822 Disease Relevance 0.08 Pain Relevance 0.15
Under the electron microscope, a sharply delineated, persistent perforation channel was shown with the Quincke needles, which may explain the high CSF loss.
Negative_regulation (loss) of CSF in CSF
17) Confidence 0.38 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9842822 Disease Relevance 0.07 Pain Relevance 0.14
The patient sustained CSF rhinorrhea which was decreased by lumbar drainage.
Negative_regulation (decreased) of CSF
18) Confidence 0.38 Published 1984 Journal No Shinkei Geka Section Abstract Doc Link 6462339 Disease Relevance 0.64 Pain Relevance 0.07
The acrylic filters, with regularly spaced cross-hatches, produced progressively more reduction in the residual CSF as the density of the cross hatching increased.
Negative_regulation (reduction) of CSF
19) Confidence 0.38 Published 1993 Journal Ophthalmic Physiol Opt Section Abstract Doc Link 8265153 Disease Relevance 0 Pain Relevance 0.08
Loss of cerebrospinal fluid (CSF) from the puncture site with a subsequent decrease in CSF pressure and an increase in transmural wall tension of the vessels might be predisposing factors for the rupture of a pre-existing cerebral aneurysm.
Negative_regulation (Loss) of CSF in CSF associated with cerebral aneurysm and rupture
20) Confidence 0.37 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1570889 Disease Relevance 0.77 Pain Relevance 0.27

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