INT115578

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 83 100.00 Very High Very High Very High
agonist 11 96.32 Very High Very High Very High
COX-2 inhibitor 2 81.36 Quite High
depression 19 77.36 Quite High
fluoxetine 11 45.72 Quite Low
sSRI 8 45.28 Quite Low
Desipramine 6 44.84 Quite Low
cINOD 1 37.76 Quite Low
COX2 1 25.00 Low Low
Dopamine 2 14.68 Low Low
Disease Link Frequency Relevance Heat
Depression 19 77.36 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Suicidal Behaviour 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How then might an effect of antidepressant agents on CDP-DG and PI synthesis be associated with the antidepressive efficacy of the compounds?
Regulation (effect) of Gene_expression (synthesis) of CDP associated with antidepressant
1) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.39
The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition.
Regulation (affected) of Gene_expression (microsomal) of CDP-choline
2) Confidence 0.02 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 14698037 Disease Relevance 0 Pain Relevance 0.07

General Comments

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