INT115579

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.82
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
plasma 2
sciatic nerve 2
brain 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 121 100.00 Very High Very High Very High
Sciatic nerve 42 99.98 Very High Very High Very High
Eae 100 99.56 Very High Very High Very High
Arthritis 80 97.52 Very High Very High Very High
Thermal hyperalgesia 20 93.08 High High
Neuropathic pain 42 92.32 High High
Inflammation 78 87.12 High High
Central nervous system 3 82.72 Quite High
Inflammatory mediators 8 75.92 Quite High
allodynia 23 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 120 99.56 Very High Very High Very High
Atherosclerosis 3 98.72 Very High Very High Very High
Experimental Arthritis 23 97.52 Very High Very High Very High
Hyperalgesia 30 93.08 High High
Calcification 5 92.88 High High
INFLAMMATION 92 87.12 High High
Arthritis 57 80.60 Quite High
Hypercalcemia 34 78.84 Quite High
Chronic Renal Failure 28 78.72 Quite High
Disease 32 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral CCI of the sciatic nerve induced a significant bilateral increase of IL-10 protein level in L4-L5 DRG as early as 1 day from the operation.
Positive_regulation (induced) of Positive_regulation (increase) of IL-10 in sciatic nerve associated with eae and sciatic nerve
1) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.70 Pain Relevance 0.48
A bilateral increase of IL-10 protein occurred in L4-L5 DRG after 14 days, when the protein level was similar to that from 3 days after CCI.
Positive_regulation (occurred) of Positive_regulation (increase) of IL-10 associated with eae
2) Confidence 0.46 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.41 Pain Relevance 0.24
The elevated TNFalpha, IL-1beta and NF-kappaB in brain were accordingly reduced, while the expression of increased IL-10 were even stimulated after repeated mirtazapine administration.
Positive_regulation (stimulated) of Positive_regulation (increased) of IL-10 in brain
3) Confidence 0.38 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.65 Pain Relevance 0.91
concentrations, approximately 30 fold increases in levels of IL6 and IL10 and a 200–300 fold elevation in synovial concentrations of TNF?
Positive_regulation (increases) of Positive_regulation (elevation) of IL10
4) Confidence 0.37 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1919375 Disease Relevance 1.19 Pain Relevance 0.44
Activation of the VDR stimulates the protective effects of type 2 helper T (Th2) cells through the induction of cytokines such as IL4 and IL10 (Boonstra et al 2001; Barrat et al 2002).
Positive_regulation (stimulates) of Positive_regulation (induction) of IL10 associated with cytokine
5) Confidence 0.19 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.63 Pain Relevance 0.05
CONCLUSIONS: Weekly paclitaxel induces transient increase in IL-10 levels whereas every 3-week higher dose treatments induce IL-8 and IL-6 in the plasma.
Positive_regulation (induces) of Positive_regulation (increase) of IL-10 in plasma
6) Confidence 0.07 Published 2004 Journal Cytokine Section Body Doc Link 14698135 Disease Relevance 0 Pain Relevance 0
The latter effect was caused primarily by an increase in IL-10 while IFN-?
Positive_regulation (caused) of Positive_regulation (increase) of IL-10
7) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 1.24 Pain Relevance 0.78

General Comments

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