INT115594

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.80
Pain Relevance 5.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 2
B cells 2
lymph nodes 1
peripheral nerve 1
Fibrocytes 1
Cd80 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 225 99.00 Very High Very High Very High
tolerance 24 98.88 Very High Very High Very High
Neuritis 11 98.84 Very High Very High Very High
Peripheral nerve injury 2 98.52 Very High Very High Very High
cytokine 38 97.64 Very High Very High Very High
chemokine 13 97.20 Very High Very High Very High
Neuropathic pain 2 96.12 Very High Very High Very High
Central nervous system 4 91.00 High High
Inflammation 69 90.24 High High
fibrosis 67 87.60 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

217 99.00 Very High Very High Very High
Optic Neuritis 11 98.84 Very High Very High Very High
Nervous System Injury 2 98.08 Very High Very High Very High
Neuropathic Pain 3 96.12 Very High Very High Very High
INFLAMMATION 72 90.24 High High
Fibrosis 4 87.60 High High
Demyelinating Disease 4 84.84 Quite High
Sprains And Strains 10 84.68 Quite High
Nephrogenic Fibrosing Dermopathy 65 82.64 Quite High
Renal Disease 6 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
Gene_expression (Presence) of CD80 in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.67 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 14698851 Disease Relevance 0.36 Pain Relevance 0.47
Particularly the fraction of DC expressing CD1a and CD80 was significantly higher in ON than in HC (P<0.05).
Gene_expression (expressing) of CD80 associated with neuritis
2) Confidence 0.64 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19948167 Disease Relevance 1.11 Pain Relevance 0.93
Professional APC express CD80 (B7-1) and related molecules, which act through CD28-related molecules on T cells.
Gene_expression (express) of B7-1 in T cells
3) Confidence 0.58 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.48 Pain Relevance 0.20
The same group52 also described a state of B cell activation, finding increased CD80 and CD86 expression, at least in a subpopulation of IBS patients.
Gene_expression (expression) of CD80 in B cell associated with spastic colon
4) Confidence 0.47 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.27 Pain Relevance 0.50
In addition, the slight but significant difference in the over expression of IgG and alpha4beta7, together with the increased expression of CD80 and CD86, suggests that IBS patients also have increased B cell activation in the extra-intestinal lymph nodes.52 In order to explain this cellular infiltrate, Ohman and Simrén47 suggested 2 possible explanations: (1) It could be due to an unregulated mild inflammation or (2) It can reflect a potent inflammatory suppressive process led by activated T lymphocytes.
Gene_expression (expression) of CD80 in lymph nodes associated with inflammation and spastic colon
5) Confidence 0.47 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.31 Pain Relevance 0.64
Bacterial component induced expression of the costimulatory molecule CD80, regarded as important for tolerance induction, is impaired.
Gene_expression (expression) of CD80 associated with tolerance
6) Confidence 0.43 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.14 Pain Relevance 0.83
B cells of IBS patients displayed an impaired ability to increase expression of CD80, but not CD86, in response to both LPS as well as probiotic bacteria stimulations.
Gene_expression (expression) of CD80 in B cells associated with spastic colon
7) Confidence 0.43 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.20 Pain Relevance 1.00
B cells isolated from blood of IBS patients displayed an amplified activation level as demonstrated by increased cell surface expression of IgG, and also the costimulatory molecules CD80 and CD86.
Gene_expression (expression) of CD80 in CD86 associated with spastic colon
8) Confidence 0.37 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19222763 Disease Relevance 0.22 Pain Relevance 1.01
It was recently found that LSEC constitutively express all molecules necessary for antigen presentation: CD54, CD80, CD86, MHC class I and II, and CD40, and can function as antigen-presenting cells for CD4+ and CD8+ T cells [67,68].
Gene_expression (express) of CD80 in CD86
9) Confidence 0.19 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.17 Pain Relevance 0.14
Fibrocytes have a specific immunophenotype and express CD34, CD11b, CD45, HLA-DR, CD71, CD80, CD86, which implies that they are recruited from the circulation and do not arise as a result of proliferation in situ.
Gene_expression (express) of CD80 in Fibrocytes
10) Confidence 0.08 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292494 Disease Relevance 1.37 Pain Relevance 0.20

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