INT1156

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 8.71
Pain Relevance 20.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
smooth muscle 4
SK-N-MC 2
fat 2
plasma 1
muscle 1
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 355 100.00 Very High Very High Very High
Opioid 26 100.00 Very High Very High Very High
opiate 15 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
antagonist 44 99.96 Very High Very High Very High
anticonvulsant 12 99.92 Very High Very High Very High
Morphine 20 99.80 Very High Very High Very High
Potency 1 99.80 Very High Very High Very High
Enkephalin 13 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Psychosis 3 100.00 Very High Very High Very High
Neuroblastoma 2 99.58 Very High Very High Very High
Anxiety Disorder 24 99.00 Very High Very High Very High
Panic Disorder 2 98.52 Very High Very High Very High
Depression 10 98.24 Very High Very High Very High
Alcohol Addiction 10 97.76 Very High Very High Very High
Obesity 7 97.20 Very High Very High Very High
Stress 4 97.08 Very High Very High Very High
Sleep Disorders 11 96.52 Very High Very High Very High
Cancer 2 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study provides indirect evidence for a cholecystokinin-opiate interaction in humans.
cholecystokinin Binding (interaction) of associated with opiate and cholecystokinin
1) Confidence 0.48 Published 1985 Journal Anesth. Analg. Section Abstract Doc Link 4014744 Disease Relevance 0.09 Pain Relevance 1.73
This antibody binds to all CCK peptides containing the sulphated tyrosine residue in position 7 and has 26% cross-reactivity with un-sulphated CCK-8, less than 2% cross-reactivity with human gastrin 1, and no cross-reactivity with structurally unrelated peptides.
CCK Binding (binds) of associated with cholecystokinin
2) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0 Pain Relevance 0.27
Gel mobility shift assays revealed that nuclear extracts prepared from a human neuroblastoma cell-line, SK-N-MC, bind to the 5'-CTGCGTCAGCG-3' motif, present within the human cholecystokinin (CCK) promoter.
cholecystokinin Binding (bind) of in SK-N-MC associated with neuroblastoma and cholecystokinin
3) Confidence 0.47 Published 1993 Journal Neuroreport Section Abstract Doc Link 8453059 Disease Relevance 0.10 Pain Relevance 0.25
Gel mobility shift assays revealed that nuclear extracts prepared from a human neuroblastoma cell-line, SK-N-MC, bind to the 5'-CTGCGTCAGCG-3' motif, present within the human cholecystokinin (CCK) promoter.
CCK Binding (bind) of in SK-N-MC associated with neuroblastoma and cholecystokinin
4) Confidence 0.47 Published 1993 Journal Neuroreport Section Abstract Doc Link 8453059 Disease Relevance 0.10 Pain Relevance 0.25
Studies in rats with the selective CCK antagonist MK-329 have helped clarify the interaction between CCK and morphine-induced analgesia.
CCK Binding (interaction) of associated with antagonist, analgesia and morphine
5) Confidence 0.45 Published 1989 Journal Pain Section Abstract Doc Link 2694075 Disease Relevance 0.57 Pain Relevance 2.07
A number of peptides, including cholecystokinin (CCK), neurotensin, and bombesin, have been shown to interact with the CNS actions of alcohol and may play a role in alcohol withdrawal.
CCK Binding (interact) of associated with withdrawal, cholecystokinin and alcohol
6) Confidence 0.42 Published 1986 Journal Recent Dev Alcohol Section Abstract Doc Link 3010391 Disease Relevance 0.40 Pain Relevance 1.05
A number of peptides, including cholecystokinin (CCK), neurotensin, and bombesin, have been shown to interact with the CNS actions of alcohol and may play a role in alcohol withdrawal.
cholecystokinin Binding (interact) of associated with withdrawal, cholecystokinin and alcohol
7) Confidence 0.42 Published 1986 Journal Recent Dev Alcohol Section Abstract Doc Link 3010391 Disease Relevance 0.40 Pain Relevance 1.05
The antagonistic interaction of CCK and opioid peptides is evident in psychological disturbances as well as stress-induced analgesia.
CCK Binding (interaction) of associated with stress, opioid, cholecystokinin and analgesia
8) Confidence 0.37 Published 2005 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 16242828 Disease Relevance 0.87 Pain Relevance 1.44
CCK participates in the mediation of satiety; it interacts with dopamine and may modulate psychosis; it interacts with opiate systems and may be an "anti-analgesic": and it appears to play a role in the mediation of anxiety.
CCK Binding (interacts) of associated with dopamine, psychosis, analgesic, anxiety disorder, opiate and cholecystokinin
9) Confidence 0.37 Published 1995 Journal J Psychiatr Res Section Abstract Doc Link 8748063 Disease Relevance 0.27 Pain Relevance 0.85
CCK participates in the mediation of satiety; it interacts with dopamine and may modulate psychosis; it interacts with opiate systems and may be an "anti-analgesic": and it appears to play a role in the mediation of anxiety.
CCK Binding (interacts) of associated with dopamine, psychosis, analgesic, anxiety disorder, opiate and cholecystokinin
10) Confidence 0.37 Published 1995 Journal J Psychiatr Res Section Abstract Doc Link 8748063 Disease Relevance 0.28 Pain Relevance 0.89
There was no relationship between integrated plasma CCK or PYY with gender, BMI, APACHE II scores on study day, serum creatinine, the type of sedation, the use of inotropes and acid suppression, presence of sepsis, or prior history of receiving enteral nutrition.
CCK Binding (integrated) of in plasma associated with sleep disorders, cholecystokinin and sepsis
11) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.41 Pain Relevance 0.45
This study compared the actions and interactions of human synthetic gastrin, octapeptide-cholecystokinin (OP-CCK), cholecystokinin (CCK), and secretin on the amplitude of isometric tension developed in strips of dog antral smooth muscle in vitro.
CCK Binding (interactions) of in smooth muscle associated with cholecystokinin
12) Confidence 0.36 Published 1979 Journal Am. J. Physiol. Section Abstract Doc Link 434148 Disease Relevance 0 Pain Relevance 0.40
Interaction between gastrin, CCK, and secretin on canine antral smooth muscle in vitro.
CCK Binding (Interaction) of in smooth muscle
13) Confidence 0.36 Published 1979 Journal Am. J. Physiol. Section Title Doc Link 434148 Disease Relevance 0 Pain Relevance 0.50
Our study supports the idea that C-terminal residue of CCK is more important for biological potency than for binding to CCK receptors.
CCK Binding (binding) of associated with potency
14) Confidence 0.36 Published 1998 Journal Peptides Section Abstract Doc Link 9493862 Disease Relevance 0.32 Pain Relevance 0.20
While increased CCK has been associated with motivational loss, anxiety and panic attacks, an increase in mesocorticolimbic opioid availability has been associated with coping and mood elevation.
CCK Binding (associated) of associated with panic disorder, anxiety disorder, opioid and cholecystokinin
15) Confidence 0.36 Published 2005 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 16242828 Disease Relevance 0.71 Pain Relevance 1.04
An increasing body of evidence supports the concept that opioid and CCK peptides may interact to control food intake, but the evidence is more suggestive than conclusive.
CCK Binding (interact) of in body associated with opioid
16) Confidence 0.36 Published 1986 Journal Physiol. Rev. Section Abstract Doc Link 2868468 Disease Relevance 0.10 Pain Relevance 0.72
The purpose of this study were 1) to quantify the lower esophageal sphincter (LES) response to intravenous cholecystokinin (CCK) in both man and the opossum in vivo, 2) to characterize the interaction of CCK and gastrin on circular muscle of the LES, and 3) to determine the site of action of CCK on LES muscle.
CCK Binding (interaction) of in muscle associated with cholecystokinin
17) Confidence 0.36 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 165733 Disease Relevance 0 Pain Relevance 0.56
The reduced contraction is caused by a lower cholecystokinin (CCK)-8 binding to CCK-1 receptors (CCK-1R) due to caveolar sequestration of receptors.
CCK Binding (binding) of associated with cholecystokinin
18) Confidence 0.35 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.30
Cholecystokinin (CCK) is structurally closely related to gastrin and shares high affinity for CCK-B/gastrin receptors.
CCK Binding (affinity) of associated with cholecystokinin
19) Confidence 0.34 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12688378 Disease Relevance 0.08 Pain Relevance 0.42
CCK-A receptors have high affinity for sulphated CCK-8 and for MK-329 but low affinity for desulphated CCK-8 and CCK-4 whilst CCK-B sites bind MK-329 with low affinity and discriminate poorly between sulphated and desulphated CCK-8.
CCK Binding (bind) of
20) Confidence 0.34 Published 1989 Journal Pain Section Abstract Doc Link 2694075 Disease Relevance 0.45 Pain Relevance 0.75

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